TAK1 signaling activity links the mast cell cytokine response and degranulation in allergic inflammation.

Szczegóły
Abstrakt

Tytuł:: TAK1 signaling activity links the mast cell cytokine response and degranulation in allergic inflammation.
Autorzy:: Watson CJF; Department of Health Sciences, Faculty of Applied Health Sciences, Cairns Family Health and Bioscience Research Complex, Brock University, Niagara Region, Ontario, Canada.
Maguire ARR; Department of Health Sciences, Faculty of Applied Health Sciences, Cairns Family Health and Bioscience Research Complex, Brock University, Niagara Region, Ontario, Canada.
Rouillard MM; Department of Health Sciences, Faculty of Applied Health Sciences, Cairns Family Health and Bioscience Research Complex, Brock University, Niagara Region, Ontario, Canada.
Crozier RWE; Department of Health Sciences, Faculty of Applied Health Sciences, Cairns Family Health and Bioscience Research Complex, Brock University, Niagara Region, Ontario, Canada.
Yousef M; Department of Health Sciences, Faculty of Applied Health Sciences, Cairns Family Health and Bioscience Research Complex, Brock University, Niagara Region, Ontario, Canada.
Bruton KM; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Fajardo VA; Department of Kinesiology, Faculty of Applied Health Sciences, Cairns Family Health and Bioscience Research Complex, Brock University, Niagara Region, Ontario, Canada.
MacNeil AJ; Department of Health Sciences, Faculty of Applied Health Sciences, Cairns Family Health and Bioscience Research Complex, Brock University, Niagara Region, Ontario, Canada.
Źródło:: Journal of leukocyte biology [J Leukoc Biol] 2020 Apr; Vol. 107 (4), pp. 649-661. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2023- : Oxford : Oxford University Press
Original Publication: New York : Alan R. Liss, c1984-
MeSH Terms:: Cell Degranulation*/drug effects
Signal Transduction*
Cytokines/*metabolism
Hypersensitivity/*enzymology
Inflammation/*pathology
MAP Kinase Kinase Kinases/*metabolism
Mast Cells/*physiology
Animals ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Calcium/metabolism ; Female ; Gene Expression Regulation/drug effects ; Hypersensitivity/genetics ; Immunoglobulin E/metabolism ; Inflammation/genetics ; Inflammation Mediators/metabolism ; MAP Kinase Kinase Kinases/antagonists & inhibitors ; Mast Cells/drug effects ; Mice, Inbred C57BL ; Models, Biological ; NF-KappaB Inhibitor alpha/genetics ; NF-KappaB Inhibitor alpha/metabolism ; NF-kappa B/metabolism ; Phosphorylation/drug effects ; Phosphoserine/metabolism ; Proto-Oncogene Proteins c-kit/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, IgE/metabolism ; Zearalenone/analogs & derivatives ; Zearalenone/pharmacology
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Contributed Indexing:: Keywords: FcεRI; MAPK signaling; NF-κB signaling; allergen-specific IgE; c-kit
Substance Nomenclature:: 0 (7-oxozeanol)
0 (Cytokines)
0 (FcepsilonRIalpha protein, mouse)
0 (Inflammation Mediators)
0 (NF-kappa B)
0 (Nfkbia protein, mouse)
0 (RNA, Messenger)
0 (Receptors, IgE)
139874-52-5 (NF-KappaB Inhibitor alpha)
17885-08-4 (Phosphoserine)
37341-29-0 (Immunoglobulin E)
5W827M159J (Zearalenone)
EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
EC 2.7.11.25 (MAP Kinase Kinase Kinases)
EC 2.7.11.25 (MAP kinase kinase kinase 7)
SY7Q814VUP (Calcium)
Entry Date(s):: Date Created: 20200229 Date Completed: 20200812 Latest Revision: 20220819
Update Code:: 20240105
DOI:: 10.1002/JLB.2A0220-401RRR
PMID:: 32108376
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Mast cells drive the inappropriate immune response characteristic of allergic inflammatory disorders via release of pro-inflammatory mediators in response to environmental cues detected by the IgE-FcεRI complex. The role of TGF-β-activated kinase 1 (TAK1), a participant in related signaling in other contexts, remains unknown in allergy. We detect novel activation of TAK1 at Ser412 in response to IgE-mediated activation under SCF-c-kit potentiation in a mast cell-driven response characteristic of allergic inflammation, which is potently blocked by TAK1 inhibitor 5Z-7-oxozeaenol (OZ). We, therefore, interrogated the role of TAK1 in a series of mast cell-mediated responses using IgE-sensitized murine bone marrow-derived mast cells, stimulated with allergen under several TAK1 inhibition strategies. TAK1 inhibition by OZ resulted in significant impairment in the phosphorylation of MAPKs p38, ERK, and JNK; and mediation of the NF-κB pathway via IκBα. Impaired gene expression and near abrogation in release of pro-inflammatory cytokines TNF, IL-6, IL-13, and chemokines CCL1, and CCL2 was detected. Finally, a significant inhibition of mast cell degranulation, accompanied by an impairment in calcium mobilization, was observed in TAK1-inhibited cells. These results suggest that TAK1 acts as a signaling node, not only linking the MAPK and NF-κB pathways in driving the late-phase response, but also initiation of the degranulation mechanism of the mast cell early-phase response following allergen recognition and may warrant consideration in future therapeutic development.
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