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Tytuł pozycji:

Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis.

Tytuł :
Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis.
Autorzy :
Zhu W; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhou BL; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Rong LJ; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Ye L; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Xu HJ; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhou Y; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Yan XJ; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Liu WD; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhu B; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Wang L; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Jiang XJ; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Ren CP; NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
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Źródło :
Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B] 2020 Feb.; Vol. 21 (2), pp. 122-136. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article; Review
Język :
English
Imprint Name(s) :
Original Publication: Hangzhou, China : Zhejiang University Press, 2005-
MeSH Terms :
Alternative Splicing*
Carcinogenesis*
Glycolysis*
Heterogeneous-Nuclear Ribonucleoproteins/*physiology
Polypyrimidine Tract-Binding Protein/*physiology
Heterogeneous-Nuclear Ribonucleoproteins/chemistry ; Humans ; MicroRNAs/physiology ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Polypyrimidine Tract-Binding Protein/chemistry ; RNA, Long Noncoding/physiology
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Contributed Indexing :
Keywords: Polypyrimidine tract-binding protein 1 (PTBP1); Alternative splicing; Glycolysis; M2 isoform of pyruvate kinase (PKM2); Cancer
Substance Nomenclature :
0 (Heterogeneous-Nuclear Ribonucleoproteins)
0 (MicroRNAs)
0 (PTBP1 protein, human)
0 (RNA, Long Noncoding)
139076-35-0 (Polypyrimidine Tract-Binding Protein)
Entry Date(s) :
Date Created: 20200303 Date Completed: 20201221 Latest Revision: 20201221
Update Code :
20210210
PubMed Central ID :
PMC7076342
DOI :
10.1631/jzus.B1900422
PMID :
32115910
Czasopismo naukowe
Polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is expressed in almost all cell types in humans, unlike the other proteins of the PTBP family. PTBP1 mediates several cellular processes in certain types of cells, including the growth and differentiation of neuronal cells and activation of immune cells. Its function is regulated by various molecules, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and RNA-binding proteins. PTBP1 plays roles in various diseases, particularly in some cancers, including colorectal cancer, renal cell cancer, breast cancer, and glioma. In cancers, it acts mainly as a regulator of glycolysis, apoptosis, proliferation, tumorigenesis, invasion, and migration. The role of PTBP1 in cancer has become a popular research topic in recent years, and this research has contributed greatly to the formulation of a useful therapeutic strategy for cancer. In this review, we summarize recent findings related to PTBP1 and discuss how it regulates the development of cancer cells.

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