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Tytuł pozycji:

Upregulation of PACE4 in prostate cancer is not dependent on E2F transcription factors.

Tytuł:
Upregulation of PACE4 in prostate cancer is not dependent on E2F transcription factors.
Autorzy:
Bakrania A; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.; Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.; Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Aubé M; Department of Surgery, Division of Urology, McGill University, Montréal, QC H3A 0G4, Canada.
Desjardins R; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.; Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.; Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Sabbagh R; Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.; Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Day R; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.; Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.; Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Źródło:
Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2020 Jul; Vol. 98 (7), pp. 477-481. Date of Electronic Publication: 2020 Mar 02.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 2011- : Ottawa, ON : Canadian Science Publishing
Original Publication: Ottawa, National Research Council of Canada.
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Adenocarcinoma/*genetics
E2F Transcription Factors/*metabolism
Proprotein Convertases/*genetics
Prostatic Neoplasms/*genetics
Serine Endopeptidases/*genetics
Adenocarcinoma/pathology ; Cell Line, Tumor ; Datasets as Topic ; E2F Transcription Factors/genetics ; Gene Expression Profiling ; Gene Knockdown Techniques ; Humans ; Male ; Prostatic Neoplasms/pathology ; Protein Isoforms/genetics ; Up-Regulation
Contributed Indexing:
Keywords: ARN interférant; E2F; PACE4; TCGA; cancer de la prostate; convertase de proprotéines; proprotein convertase; prostate cancer; siRNA; transfection
Substance Nomenclature:
0 (E2F Transcription Factors)
0 (Protein Isoforms)
EC 3.4.21.- (PCSK6 protein, human)
EC 3.4.21.- (Proprotein Convertases)
EC 3.4.21.- (Serine Endopeptidases)
Entry Date(s):
Date Created: 20200303 Date Completed: 20210208 Latest Revision: 20210208
Update Code:
20240105
DOI:
10.1139/cjpp-2019-0668
PMID:
32119574
Czasopismo naukowe
Recent studies in prostate cancer have identified PACE4, a proprotein convertase enzyme, as an emerging therapeutic target. Inhibition of PACE4-altCT, an oncogenic isoform of PACE4, using molecular or pharmacological approaches results in decreased cell proliferation and tumor progression in xenograft models. Although several validations have confirmed PACE4-altCT as a novel therapeutic target, the transcriptional regulation of PACE4 isoforms and mechanism of action remain a challenge. Previously, it has been reported that the human PACE4 promoter possesses potential binding sites for the E2F family of transcription factors, all of which are involved in cell cycle regulation and synthesis of DNA in mammalian cells. Therefore, we attempted to conduct in-depth evaluation of E2Fs on PACE4 and PACE4 isoform expression in prostate cancer. We conducted in vitro molecular silencing studies in various prostate cancer cell lines and determined the change in PACE4 expression levels. The results clearly show that the E2Fs alone do not alter PACE4 expression.

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