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Tytuł pozycji:

Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG.

Tytuł:
Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG.
Autorzy:
Yaojia Cheng YX; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
Lu Q; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
Shi N; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
Zhou Q; Department of Dermatology, Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Rong J; Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China.
Li L; Information Centre, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
Wang L; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
Liu C; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
Źródło:
International journal of molecular medicine [Int J Mol Med] 2020 Apr; Vol. 45 (4), pp. 1163-1175. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Athens, Greece : D.A. Spandidos, [1998-
MeSH Terms:
Nonsense Mediated mRNA Decay*
Signal Transduction*
Amphiregulin/*metabolism
Keratinocytes/*metabolism
Psoriasis/*metabolism
RNA Helicases/*metabolism
Trans-Activators/*biosynthesis
Trans-Activators/*metabolism
Amphiregulin/genetics ; Animals ; Disease Models, Animal ; Female ; Humans ; Keratinocytes/pathology ; Male ; Mice ; Protein Stability ; Psoriasis/genetics ; Psoriasis/pathology ; RNA Helicases/genetics ; Trans-Activators/genetics
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Substance Nomenclature:
0 (AREG protein, human)
0 (Amphiregulin)
0 (Areg protein, mouse)
0 (Rent1 protein, mouse)
0 (Trans-Activators)
EC 3.6.4.13 (RNA Helicases)
EC 3.6.4.13 (UPF1 protein, human)
Entry Date(s):
Date Created: 20200304 Date Completed: 20201130 Latest Revision: 20201130
Update Code:
20240105
PubMed Central ID:
PMC7053862
DOI:
10.3892/ijmm.2020.4487
PMID:
32124941
Czasopismo naukowe
The up‑frameshift suppressor 1 homolog (UPF1) RNA surveillance gene is a core element in the nonsense‑mediated RNA decay (NMD) pathway, which impacts a broad spectrum of biological processes in a cell‑specific manner. In the present study, the contribution of the NMD pathway to psoriasis lesions and its moderating effects on the biological processes of keratinocytes was reported. Sanger sequencing for skin scales from two patients with psoriasis identified two mRNA mutations (c.2935_2936insA and c.2030‑2081del) in the UPF1 gene. The somatic mutants produced truncated UPF1 proteins and perturbed the NMD pathway in cells, leading to the upregulation of NMD substrates. As the most abundant epidermal growth factor receptor ligand in keratinocytes, it was concluded that amphiregulin (AREG) mRNA is a natural NMD substrate, that is dependent on its 3' untranslated region sequence. Perturbed NMD modulated keratinocyte homeostasis in an AREG‑dependent but nonidentical manner, which highlighted the unique characteristics of NMD in keratinocytes. By targeting AREG mRNA post‑transcriptionally, the UPF1‑NMD pathway contributed to an imbalance between proliferation on the one hand, and apoptosis and abnormal differentiation, migration and inflammatory response on the other, in keratinocytes, which indicated a role of the NMD pathway in the full development of keratinocyte‑related morbidity and skin diseases.

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