Oral Human Papillomavirus: a multisite infection.

Szczegóły
Abstrakt

Tytuł:: Oral Human Papillomavirus: a multisite infection.
Autorzy:: Criscuolo MI; School of Dentistry Universidad Nacional de Córdoba Haya de la Torre s/n, Córdoba, Argentina .
Morelatto RA
Belardinelli PA
Mosmann JM
Cuffini C
López de Blanc SA
Źródło:: Medicina oral, patologia oral y cirugia bucal [Med Oral Patol Oral Cir Bucal] 2020 May 01; Vol. 25 (3), pp. e425-e430. Date of Electronic Publication: 2020 May 01.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Valencia, España : Medicina Oral S.L., [2004]-
MeSH Terms:: Mouth Neoplasms*
Papillomaviridae*
Papillomavirus Infections*
Case-Control Studies ; DNA, Viral ; Humans
References:: J Med Virol. 2010 Aug;82(8):1424-30. (PMID: 20572068)
Clin Sci (Lond). 2006 May;110(5):525-41. (PMID: 16597322)
Arch Oral Biol. 2017 Nov;83:334-339. (PMID: 28886585)
PLoS One. 2014 Mar 20;9(3):e92208. (PMID: 24651691)
J Clin Virol. 2005 Mar;32 Suppl 1:S43-51. (PMID: 15753011)
BMC Med Inform Decis Mak. 2019 Jul 25;19(1):141. (PMID: 31340796)
BMC Infect Dis. 2014 Dec 16;14:671. (PMID: 25510243)
Clin Microbiol Rev. 2012 Apr;25(2):215-22. (PMID: 22491770)
Oncology. 2018;94(3):133-141. (PMID: 29241220)
Crit Rev Oncol Hematol. 2016 Jan;97:157-67. (PMID: 26346895)
J Oral Pathol Med. 2007 Sep;36(8):482-7. (PMID: 17686007)
Oral Dis. 2008 May;14(4):356-66. (PMID: 18410578)
Int J Clin Oncol. 2016 Oct;21(5):827-835. (PMID: 27380170)
Oral Dis. 2011 Apr;17 Suppl 1:58-72. (PMID: 21382139)
J Med Virol. 2017 Jun;89(6):1121-1124. (PMID: 27935070)
Math Biosci. 2015 Dec;270(Pt A):115-25. (PMID: 26518265)
J Med Virol. 2018 Feb;90(2):358-366. (PMID: 28906006)
AIDS Res Hum Retroviruses. 2012 Dec;28(12):1734-8. (PMID: 22519744)
PLoS One. 2015 Oct 05;10(10):e0139524. (PMID: 26437318)
Braz J Otorhinolaryngol. 2010 Jan-Feb;76(1):78-84. (PMID: 20339693)
Int J Cancer. 2005 Nov 20;117(4):605-10. (PMID: 15929076)
Crit Rev Oral Biol Med. 2004 Jul 01;15(4):188-96. (PMID: 15284184)
Int J Oral Maxillofac Surg. 2010 Jul;39(7):678-83. (PMID: 20413270)
Infect Agent Cancer. 2008 Feb 28;3:3. (PMID: 18307798)
J Clin Virol. 2005 Mar;32 Suppl 1:S59-66. (PMID: 15753013)
Substance Nomenclature:: 0 (DNA, Viral)
Entry Date(s):: Date Created: 20200306 Date Completed: 20200414 Latest Revision: 20200516
Update Code:: 20240105
PubMed Central ID:: PMC7211376
DOI:: 10.4317/medoral.23462
PMID:: 32134899
: Czasopismo naukowe

Background: The Human Papillomavirus (HPV) has different strategies for persist in the cells. This characteristic has led us to consider the presence of the virus in tissues of the oral cavity that had no clinical signs of infection. The aim of this study was to detect the presence of DNA-HPV at multiple sites of the oral cavity.
Material and Methods: A case-control study was designed: Oral Squamous Carcinoma Group (OSCG), healthy n=72 and Control Group (CG), n=72, healthy volunteers paired by sex and age with OSCG. Four samples were taken from OSCG: saliva, biopsy, brush scraping of lesion and contralateral healthy side. In CG a saliva sample and a scratch of the posterior border of tongue were collected. HPV was detected by PCR using Bioneer Accuprep genomic DNA Extraction kit, and consensus primers MY09 and MY11. Chi square test was applied.
Results: 432 samples were obtained from 144 individuals. DNA-HPV was detected in 30 (42%) of OSCG subjects and 3(4%) of CG. Two or more positive samples were obtained in 67% of the OSCG, 67% in saliva and 60% in biopsy; in CG 100% of the individuals were positive in the two samples.
Conclusions: HPV is frequently present in oral cavity as a multifocal infection, even without the presence of clinical lesions.

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