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Tytuł:
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Palmatine alleviates hyperalgesia by inhibiting the expression of calcitonin gene-related peptide in the trigeminal ganglion of rats with chronic constriction injury of the infraorbital nerve.
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Autorzy:
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He L; Affiliated Stomatological Hospital of Nanchang University, Nanchang, Jiangxi, China.
Liu L; Affiliated Stomatological Hospital of Nanchang University, Nanchang, Jiangxi, China.
Guan S; Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zheng X; Queen Mary college of grade 2015, Nanchang University, Nanchang, Jiangxi, China.
Ge H; Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, China.
Yin C; Affiliated Stomatological Hospital of Nanchang University, Nanchang, Jiangxi, China.
Shen Y; Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, China.
Tan M; Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, China.
Wang C; Second Clinic Medical College of Grade 2017, Nanchang University, Nanchang, Jiangxi, China.
Gao Y; Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, China.
Xiong W; Affiliated Stomatological Hospital of Nanchang University, Nanchang, Jiangxi, China; Jiangxi Provincial Key Laboratory of Oral Biomedicine, Nanchang, Jiangxi, China. Electronic address: .
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Źródło:
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The British journal of oral & maxillofacial surgery [Br J Oral Maxillofac Surg] 2020 May; Vol. 58 (4), pp. 443-450. Date of Electronic Publication: 2020 Mar 02.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Edinburgh, U.K. : Churchill Livingstone, c1984-
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MeSH Terms:
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Calcitonin Gene-Related Peptide*
Trigeminal Ganglion*
Animals ; Berberine Alkaloids ; Calcitonin ; Constriction ; Humans ; Hyperalgesia ; Male ; Quality of Life ; Rats ; Rats, Sprague-Dawley
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Contributed Indexing:
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Keywords: Calcitonin-gene-related peptide; Chronic constriction injury of the infraorbital nerve; Palmatine; Trigeminal neuralgia
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Substance Nomenclature:
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0 (Berberine Alkaloids)
9007-12-9 (Calcitonin)
G50C034217 (palmatine)
JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
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Entry Date(s):
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Date Created: 20200307 Date Completed: 20201014 Latest Revision: 20201014
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Update Code:
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20240105
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DOI:
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10.1016/j.bjoms.2020.01.031
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PMID:
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32139146
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Trigeminal neuralgia is one of the most common of the neuropathic pains, and it can seriously influence patients' quality of life. Calcitonin gene-related peptide (CGRP) is a type of nociceptive neurotransmitter that is expressed in neurons of the trigeminal ganglion and plays a major part in transmitting pain. The rat model of trigeminal neuralgia was established by causing a chronic constriction injury of the infraorbital nerve (CCI-ION). Male Sprague-Dawley rats (n=24) were randomly divided into a sham control group (sham, n=6), sham-treated with palmatine group (sham+palmatine, n=6), trigeminal nerve model group (TN, n=6), and trigeminal nerve treated with palmatine group (TN+palmatine, n=6). Fifteen days after the operation the mechanical response threshold was decreased in the TN group compared with the sham group. From postoperative day 7 to day 15, the mechanical response threshold in the TN+palmatine group significantly increased compared with the TN group. On postoperative day 15 the results of quantitative polymerase chain reaction (qPCR), immunohistochemical staining, and western blotting showed an obvious increase in expression of CGRP and its receptors, serum concentrations of interleukin-1β (IL-1β), and tumour necrosis factor-α (TNF-α), and phosphorylation of protein kinase C (PKC) in the trigeminal ganglia of the TN group compared with the sham group, but these increases could be down-regulated by treatment with palmatine. Palmatine might therefore have therapeutic potential for the treatment of trigeminal neuralgia by inhibiting the expression of CGRP and its receptors in trigeminal ganglia, suppressing the serum concentrations of IL-1β and TNF-α, and decreasing the phosphorylation of PKC in the trigeminal ganglia of affected rats.
(Copyright © 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)
