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Tytuł pozycji:

Ultrasound elastography in characterization of prostatic lesions: correlation with histopathological findings.

Tytuł :
Ultrasound elastography in characterization of prostatic lesions: correlation with histopathological findings.
Autorzy :
Emara DM; Department of radiodiagnosis and intervention, faculty of medicine, Alexandria university, Alexandria, Egypt.
Naguib NN; AMEOS Hospital Halberstadt, Halberstadt, Germany.
Yehia M; Department of Urology, faculty of medicine, Alexandria university, Alexandria, Egypt.
El Shafei MM; Department of radiodiagnosis and intervention, faculty of medicine, Alexandria university, Alexandria, Egypt.
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Źródło :
The British journal of radiology [Br J Radiol] 2020 Jun; Vol. 93 (1110), pp. 20200035. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: London, British Institute of Radiology.
MeSH Terms :
Elasticity Imaging Techniques/*methods
Prostate/*diagnostic imaging
Prostatic Neoplasms/*diagnostic imaging
Aged ; Echocardiography, Doppler, Color ; Humans ; Image-Guided Biopsy/methods ; Male ; Middle Aged ; Neoplasm Grading ; Predictive Value of Tests ; Prospective Studies ; Prostate/pathology ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/pathology ; Sample Size ; Sensitivity and Specificity
Substance Nomenclature :
EC 3.4.21.77 (Prostate-Specific Antigen)
Entry Date(s) :
Date Created: 20200307 Date Completed: 20200604 Latest Revision: 20200604
Update Code :
20210210
DOI :
10.1259/bjr.20200035
PMID :
32142374
Czasopismo naukowe
Objective: Ultrasound elastography is increasingly used in the diagnosis of prostate cancer, however results are heterogeneous. We correlate in a large sample-size prospective study the accuracy of elastography, aiming to settle an accurate cut-off point for diagnosis and possibility of use as a screening tool.
Methods: Prospective study that included 120 patients with mean age 59.5 ± 9.8 years, showing enlarged prostate by clinical examination with prostate-specific antigen >4 ng ml -1 .The study was done using high frequency high resolution endorectal probe with real time tissue elastography.Grayscale ultrasound examination was done first with Doppler followed by elastography color-coded map and strain ratio measurement. Then, transrectal ultrasound-guided core biopsy was done from suspicious areas detected by elastography (totally or partly stiff by color-coded map or with relative increased strain ratio), besides standard six-quadrant core biopsy samples.
Results: There was statistically significant difference ( p < 0.001) regarding strain ratio in benign and malignant lesions. Strain ratio showed significant proportionate correlation with prostate-specific antigen level and Gleason pathological score, while no significant correlation noted with the age or the prostatic volume. A strain ratio with a cut-off value of 1.9 showed a sensitivity of 100%, specificity 93.8%, positive predictive value of 79.3%, negative predictive value 100 and 95% accuracy in differentiating between malignant and benign lesions.
Conclusion: Strain ratio improves the detection of prostatic cancer with high sensitivity (100%) and high negative predictive value (100%).
Advances in Knowledge: Different prostatic lesions are mostly similar in grayscale ultrasound.Imaging plays an important role in differentiation of prostatic nodules.Ultrasound elastography may play an important role in distinguishing benign from malignant nodules.

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