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Tytuł:
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[Hereditary gastric cancer: Challenges for the pathologist in 2020].
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Autorzy:
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Renaud F; Sorbonne université, Inserm, unité Mixte de Recherche Scientifique 938, SIRIC CURAMUS, centre de recherche Saint-Antoine, équipe instabilité des microsatellites et cancer, équipe labellisée par la Ligue Nationale contre le cancer, 75012 Paris, France; Service d'anatomie et cytologie pathologiques, hôpital Saint-Antoine, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France. Electronic address: .
Svrcek M; Sorbonne université, Inserm, unité Mixte de Recherche Scientifique 938, SIRIC CURAMUS, centre de recherche Saint-Antoine, équipe instabilité des microsatellites et cancer, équipe labellisée par la Ligue Nationale contre le cancer, 75012 Paris, France; Service d'anatomie et cytologie pathologiques, hôpital Saint-Antoine, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France.
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Transliterated Title:
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Les cancers gastriques héréditaires: rôle du pathologiste en 2020.
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Źródło:
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Annales de pathologie [Ann Pathol] 2020 Apr; Vol. 40 (2), pp. 95-104. Date of Electronic Publication: 2020 Mar 05.
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Typ publikacji:
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Journal Article; Review
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Język:
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French
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Imprint Name(s):
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Original Publication: Paris ; New York : Masson, c1981-
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MeSH Terms:
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Adenomatous Polyps*/diagnosis
Adenomatous Polyps*/genetics
Adenomatous Polyps*/pathology
Colorectal Neoplasms, Hereditary Nonpolyposis*/diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Colorectal Neoplasms, Hereditary Nonpolyposis*/pathology
Neoplastic Syndromes, Hereditary*/diagnosis
Neoplastic Syndromes, Hereditary*/pathology
Stomach Neoplasms*/diagnosis
Stomach Neoplasms*/genetics
Stomach Neoplasms*/pathology
Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Carcinogens ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Diagnosis, Differential ; Genetic Predisposition to Disease ; Humans ; Immunohistochemistry ; Pathologists/education ; Stomach/pathology
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Contributed Indexing:
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Keywords: Cancer gastrique héréditaire diffus; Cancers héréditaires de l’estomac; GAPPS; Hereditary diffuse gastric cancer; Hereditary gastric cancer; Immunohistochemistry; Immunohistochimie; Lynch syndrome; Oncogenetics; Oncogénétique; Syndrome de Lynch
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Substance Nomenclature:
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0 (Carcinogens)
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SCR Disease Name:
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Polyposis, Gastric
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Entry Date(s):
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Date Created: 20200310 Date Completed: 20210217 Latest Revision: 20210217
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Update Code:
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20240105
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DOI:
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10.1016/j.annpat.2020.02.007
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PMID:
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32147190
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Gastric cancer is the third most common cancer worldwide. The majority of gastric cancers are sporadic but familial clustering is seen in more than 10% of cases. This manuscript is divided into two parts. The first part is dedicated to the non-syndromic hereditary gastric cancer, particularly the hereditary diffuse gastric cancer (HDGC) and other gastric polyposes including the recently described GAPPS (Gastric adenocarcinoma and proximal polyposis of the stomach). The second part concerns the syndromic gastric cancer, namely the HNPCC syndrome (Hereditary Non Polyposis Colorectal Cancer) occurring as part of a genetic predisposition syndrome to cancer. Recent advances in oncogenetics and next generation sequencing technology have enabled the identification of new entities. This enhancement in knowledge regarding inherited syndromes predisposing to gastric cancer has consequently improved the management of patients and their families. In this context, pathologists play a major role in identifying particular morphologic entities prompting genetic investigation. The aim of this manuscript is to provide an update on the current knowledge about hereditary gastric cancer.
(Copyright © 2020 Elsevier Masson SAS. All rights reserved.)
