-
Tytuł:
-
Rescue role of hesperidin in 4-vinylcyclohexene diepoxide-induced toxicity in the brain, ovary and uterus of wistar rats.
-
Autorzy:
-
Abolaji AO; Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria, Phone: +2348068614194.
Omozokpia MU; Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Oluwamuyide OJ; Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Akintola TE; Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Farombi EO; Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria, Phone: +2348023470333.
-
Źródło:
-
Journal of basic and clinical physiology and pharmacology [J Basic Clin Physiol Pharmacol] 2020 Mar 11; Vol. 31 (2). Date of Electronic Publication: 2020 Mar 11.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Jun. 2011- : Berlin : Walter de Gruyter
Original Publication: London, England : Freund Pub. House, c1990-
-
MeSH Terms:
-
Brain/*drug effects
Cyclohexenes/*toxicity
Hesperidin/*pharmacology
Ovary/*drug effects
Uterus/*drug effects
Vinyl Compounds/*toxicity
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Brain/pathology ; Female ; Glutathione/metabolism ; Ovary/pathology ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Uterus/pathology
-
Contributed Indexing:
-
Keywords: 4-vinylcyclohexene diepoxide; hesperidin; oxidative damage; reproductive toxicity
-
Substance Nomenclature:
-
0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Cyclohexenes)
0 (Vinyl Compounds)
596C064IG4 (4-vinyl-1-cyclohexene dioxide)
E750O06Y6O (Hesperidin)
GAN16C9B8O (Glutathione)
-
Entry Date(s):
-
Date Created: 20200312 Date Completed: 20201217 Latest Revision: 20201217
-
Update Code:
-
20240105
-
DOI:
-
10.1515/jbcpp-2018-0115
-
PMID:
-
32160159
-
Background The ovotoxicity of 4-vinylcyclohexene diepoxide (VCD) has been established in several experimental models. Hesperidin (HSD) is a bi-flavonoid found in citrus fruits and has been reported to be a potent antioxidant and anti-inflammatory agent. Here, we have evaluated the rescue role of hesperidin on VCD-induced toxicity in the brain, ovary, and uterus of rats. Methods Six groups of rats containing ten rats in each group were orally given corn oil (control), hesperidin (100 mg/kg), hesperidin (200 mg/kg), VCD (250 mg/kg), VCD [(250 mg/kg)+hesperidin (100 mg/kg)] and VCD [(250 mg/kg)+hesperidin (200 mg/kg)] once a day for 30 days, respectively. Thereafter, we determined the selected biomarkers of oxidative damage, inflammation, endocrine balance, and histology of the reproductive organs. Results The data showed that hesperidin rescued VCD-induced increase in oxidative stress (hydrogen peroxide and malondialdehyde) and inflammatory (nitric oxide) biomarkers. In addition, hesperidin restored the reduction in antioxidant enzymes (catalase, glutathione S-transferase, glutathione peroxidase) activities and glutathione level in the brain, ovary, and uterus of rats (p<0.05). Lastly, hesperidin preserved the histological structure of the ovary and uterus of rats exposed to VCD. Conclusions Overall, the rescue role of hesperidin on VCD-induced toxicity in the brain and reproductive organs of female rats may be due to its antioxidative and anti-inflammatory properties.
