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Tytuł pozycji:

Chlorpyrifos-induced cell proliferation in human breast cancer cell lines differentially mediated by estrogen and aryl hydrocarbon receptors and KIAA1363 enzyme after 24 h and 14 days exposure.

Tytuł :
Chlorpyrifos-induced cell proliferation in human breast cancer cell lines differentially mediated by estrogen and aryl hydrocarbon receptors and KIAA1363 enzyme after 24 h and 14 days exposure.
Autorzy :
Moyano P; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacology, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Muñoz-Calero P; Alborada Foundation, 28690, Brunete, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Lobo M; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain.
Del Pino J; Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2020 Jul; Vol. 251, pp. 126426. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford, New York, : Pergamon Press.
MeSH Terms :
Chlorpyrifos/*toxicity
Insecticides/*toxicity
Receptors, Aryl Hydrocarbon/*metabolism
Sterol Esterase/*metabolism
Cell Proliferation/drug effects ; Chlorpyrifos/analogs & derivatives ; Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 CYP1B1 ; Estrogen Receptor alpha ; Estrogens/pharmacology ; Humans ; MCF-7 Cells ; Tumor Cells, Cultured
Contributed Indexing :
Keywords: AhR; CYP1A1; Chlorpyrifos; ER; KIAA163; MCF-7; MDA-MB-231
Substance Nomenclature :
0 (Estrogen Receptor alpha)
0 (Estrogens)
0 (Insecticides)
0 (Receptors, Aryl Hydrocarbon)
0 (estrogen receptor alpha, human)
5598-15-2 (O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate)
EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
EC 1.14.14.1 (Cytochrome P-450 CYP1B1)
EC 3.1.1.13 (NCEH1 protein, human)
EC 3.1.1.13 (Sterol Esterase)
JCS58I644W (Chlorpyrifos)
Entry Date(s) :
Date Created: 20200316 Date Completed: 20200603 Latest Revision: 20200603
Update Code :
20201218
DOI :
10.1016/j.chemosphere.2020.126426
PMID :
32171938
Czasopismo naukowe
Organophosphate biocide chlorpyrifos (CPF) is involved with breast cancer. However, the mechanisms remain unknown. CPF increases cell division in MCF-7 cells, by estrogen receptor alpha (ERα) activation, although it is a weak ERα agonist, suggesting other mechanisms should be involved. Aromatic hydrocarbon receptor (AhR) activation increases cell division in human breast cancer cells, and CPF strongly activates it. Finally, the KIAA1363 enzyme, which is regulated by CPF, is overexpressed in cancer cells. Accordingly, we hypothesized that CPF or its metabolite chlorpyrifos-oxon (CPFO) could induce cell viability promotion in MCF-7 and MDA-MB-231 cell lines, through mechanisms related to ERα, AhR, and KIAA1363, after 24 h and 14 days treatment. Results show that, after acute and long-term treatment, CPF and CPFO alter differently KIAA1363, AhR, ER and cytochrome P450 isoenzyme 1A1 (CYP1A1) expression. In addition, they induced cell proliferation through ERα activation after 24 h exposure in MCF-7 cells and through KIAA1363 overexpression and AhR activation in MCF-7 and MDA-MB-231 cells after acute and long-term treatment. The results obtained in this work provide new information relative to the mechanisms involved in the CPF toxic effects that could lead to breast cancer disease.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)

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