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Tytuł pozycji:

Comparison of neoadjuvant treatments followed by radical surgery or chemoradiation on quality of life in patients with stage IB2-IIA cervical cancer.

Tytuł:
Comparison of neoadjuvant treatments followed by radical surgery or chemoradiation on quality of life in patients with stage IB2-IIA cervical cancer.
Autorzy:
Sun Z; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, PR China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, PR China.
Huang B; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, PR China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, PR China.
Liu C; Department of Gynecological Oncology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, PR China.
Yang Y; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, PR China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, PR China.
Rao Y; Department of Gynecological Oncology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, PR China.
Du Y; Department of Social Medicine and Health Service Management, School of Public Health, Tianjin Medical University, Tianjin, PR China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, PR China.
Ma Y; Department of Gynecological Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, PR China. Electronic address: .
Źródło:
Gynecologic oncology [Gynecol Oncol] 2020 May; Vol. 157 (2), pp. 536-541. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: New York, Academic Press.
MeSH Terms:
Uterine Cervical Neoplasms/*therapy
Chemoradiotherapy ; Female ; Humans ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Quality of Life ; Retrospective Studies ; Socioeconomic Factors ; Uterine Cervical Neoplasms/economics ; Uterine Cervical Neoplasms/pathology
Contributed Indexing:
Keywords: Cervical cancer; Chemoradiation; Neoadjuvant treatments; Quality of life; Radical surgery
Entry Date(s):
Date Created: 20200317 Date Completed: 20201030 Latest Revision: 20201030
Update Code:
20240105
DOI:
10.1016/j.ygyno.2020.01.039
PMID:
32173046
Czasopismo naukowe
Objective: To compare quality of life (Qol) of patients with stage IB2-IIA cervical cancer treated by neoadjuvant treatments followed by radical surgery (NTS) or standard chemoradiation (CRT).
Methods: Patients with stage IB2-IIA cervical cancer during 2006-2012 were treated with NTS or CRT and were invited to participate. The Functional Assessment of Cancer Therapy-Cervix (FACT-Cx) Questionnaire was used to assess patient Qol. A multivariable linear regression analysis was performed to identify factors associated with Qol.
Results: In total, 90 (78.3%) out of 115 eligible patients completed the questionnaires. No significant differences were found in Qol between treatment groups, except that patients after NTS reported higher scores in the social/family well-being (e.g. satisfaction with sexual life, close relationships with partner or friends, and support from friends) than those after CRT, in particular, during 2-3 years after treatment. Results of multivariate analysis indicated that NTS was associated with better social/family functioning, while advanced stage of cervical cancer, lower family income and lower education were associated with impaired Qol in different domains.
Conclusions: Although self-reported Qol after treatment were not significantly different, NTS treated patients reported better social/family functioning than CRT treated patients, such as satisfaction with their sexual life and close relationships with partner or friends, during 2-3 years post treatment. These results were helpful for physicians to make treatment decisions while considering treatment-related Qol, and moreover, for rehabilitation and supportive care of patients after treatment. Further validation of our findings in randomized, controlled clinical trials is warranted.
Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest.
(Copyright © 2020. Published by Elsevier Inc.)

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