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Tytuł pozycji:

Accumulation of Pericardial Fat Is Associated With Alterations in Heart Rate Variability Patterns in Hypercholesterolemic Pigs.

Tytuł :
Accumulation of Pericardial Fat Is Associated With Alterations in Heart Rate Variability Patterns in Hypercholesterolemic Pigs.
Autorzy :
Uceda DE; Division of Nephrology and Hypertension (D.E.U., X.-Y.Z., J.R.W., C.M.F., I.P., L.O.L.), Mayo Clinic, Rochester, MN.
Zhu XY; Division of Nephrology and Hypertension (D.E.U., X.-Y.Z., J.R.W., C.M.F., I.P., L.O.L.), Mayo Clinic, Rochester, MN.
Woollard JR; Division of Nephrology and Hypertension (D.E.U., X.-Y.Z., J.R.W., C.M.F., I.P., L.O.L.), Mayo Clinic, Rochester, MN.
Ferguson CM; Division of Nephrology and Hypertension (D.E.U., X.-Y.Z., J.R.W., C.M.F., I.P., L.O.L.), Mayo Clinic, Rochester, MN.
Patras I; Division of Nephrology and Hypertension (D.E.U., X.-Y.Z., J.R.W., C.M.F., I.P., L.O.L.), Mayo Clinic, Rochester, MN.
Carlson DF; Recombinetics, Inc, St. Paul, MN (D.F.C.).
Asirvatham SJ; Department of Cardiovascular Diseases (S.J.A., A.L., L.O.L.), Mayo Clinic, Rochester, MN.
Lerman A; Department of Cardiovascular Diseases (S.J.A., A.L., L.O.L.), Mayo Clinic, Rochester, MN.
Lerman LO; Division of Nephrology and Hypertension (D.E.U., X.-Y.Z., J.R.W., C.M.F., I.P., L.O.L.), Mayo Clinic, Rochester, MN.; Department of Cardiovascular Diseases (S.J.A., A.L., L.O.L.), Mayo Clinic, Rochester, MN.
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Źródło :
Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2020 Apr; Vol. 13 (4), pp. e007614. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Język :
English
Imprint Name(s) :
Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins
MeSH Terms :
Adiposity*
Heart Rate*
Adipose Tissue/*physiopathology
Arrhythmias, Cardiac/*etiology
Autonomic Nervous System/*physiopathology
Hypercholesterolemia/*complications
Inflammation/*etiology
Pericardium/*physiopathology
Adipose Tissue/metabolism ; Animals ; Animals, Genetically Modified ; Arrhythmias, Cardiac/metabolism ; Arrhythmias, Cardiac/physiopathology ; Autonomic Nervous System/metabolism ; Cholesterol/blood ; Disease Models, Animal ; Hypercholesterolemia/metabolism ; Hypercholesterolemia/physiopathology ; Inflammation/metabolism ; Inflammation/physiopathology ; Inflammation Mediators/metabolism ; Male ; Norepinephrine/blood ; Pericardium/metabolism ; Swine ; Swine, Miniature/genetics ; Time Factors ; Tumor Necrosis Factor-alpha/metabolism
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Grant Information :
R01 DK122734 United States DK NIDDK NIH HHS; R25 HL092621 United States HL NHLBI NIH HHS; U01 DK104273 United States DK NIDDK NIH HHS; R01 DK102325 United States DK NIDDK NIH HHS; R01 DK120292 United States DK NIDDK NIH HHS
Contributed Indexing :
Keywords: animals*; cholesterol*; heart rate*; inflammation*; swine*
Substance Nomenclature :
0 (Inflammation Mediators)
0 (Tumor Necrosis Factor-alpha)
97C5T2UQ7J (Cholesterol)
X4W3ENH1CV (Norepinephrine)
Entry Date(s) :
Date Created: 20200320 Date Completed: 20200817 Latest Revision: 20200817
Update Code :
20201023
PubMed Central ID :
PMC7195699
DOI :
10.1161/CIRCEP.119.007614
PMID :
32189516
Czasopismo naukowe
Background: Heart rate variability (HRV) and pulse rate variability are indices of autonomic cardiac modulation. Increased pericardial fat is associated with worse cardiovascular outcomes. We hypothesized that progressive increases in pericardial fat volume and inflammation prospectively dampen HRV in hypercholesterolemic pigs.
Methods: WT (wild type) or PCSK9 (proprotein convertase subtilisin-like/kexin type-9) gain-of-function Ossabaw mini-pigs were studied in vivo before and after 3 and 6 months of a normal diet (WT-normal diet, n=4; PCSK9-normal diet, n=6) or high-fat diet (HFD; WT-HFD, n=3; PCSK9-HFD, n=6). The arterial pulse waveform was obtained from an arterial telemetry transmitter to analyze HRV indices, including SD (SD of all pulse-to-pulse intervals over a single 5-minute period), root mean square of successive differences, proportion >50 ms of normal-to-normal R-R intervals, and the calculated ratio of low-to-high frequency distributions (low-frequency power/high-frequency power). Pericardial fat volumes were evaluated using multidetector computed tomography and its inflammation by gene expression of TNF (tumor necrosis factor)-α. Plasma lipid panel and norepinephrine level were also measured.
Results: At diet completion, hypercholesterolemic PCSK9-HFD had significantly ( P <0.05 versus baseline) depressed HRV (SD of all pulse-to-pulse intervals over a single 5-minute period, root mean square of successive differences, proportion >50 ms, high-frequency power, low-frequency power), and both HFD groups had higher sympathovagal balance (SD of all pulse-to-pulse intervals over a single 5-minute period/root mean square of successive differences, low-frequency power/high-frequency power) compared with normal diet. Pericardial fat volumes and LDL (low-density lipoprotein) cholesterol concentrations correlated inversely with HRV and directly with sympathovagal balance, while sympathovagal balance correlated directly with plasma norepinephrine. Pericardial fat TNF-α expression was upregulated in PCSK9-HFD, colocalized with nerve fibers, and correlated inversely with root mean square of successive differences and proportion >50 ms.
Conclusions: Progressive pericardial fat expansion and inflammation are associated with a fall in HRV in Ossabaw mini-pigs, implying aggravated autonomic imbalance. Hence, pericardial fat accumulation is associated with alterations in HRV and the autonomic nervous system. Visual Overview: A visual overview is available for this article.

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