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Tytuł:
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Acute Liver Failure Caused by Use of Fat Burner: A Case Report.
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Autorzy:
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Ferreira GSA; Liver Transplant Division, Federal District Cardiology Institute, Brasilia, Brazil. Electronic address: .
Watanabe ALC; Liver Transplant Division, Federal District Cardiology Institute, Brasilia, Brazil.
Trevizoli NC; Liver Transplant Division, Federal District Cardiology Institute, Brasilia, Brazil.
Jorge FMF; Liver Transplant Division, Federal District Cardiology Institute, Brasilia, Brazil.
Diaz LGG; Liver Transplant Division, Federal District Cardiology Institute, Brasilia, Brazil.
Couto CF; Liver Transplant Division, Federal District Cardiology Institute, Brasilia, Brazil.
Lima LV; School of Medicine, Catholic University of Brasilia, Brasilia, Brazil.
Raupp DRL; School of Medicine, Catholic University of Brasilia, Brasilia, Brazil.
Araujo BE; School of Medicine, Catholic University of Brasilia, Brasilia, Brazil.
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Źródło:
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Transplantation proceedings [Transplant Proc] 2020 Jun; Vol. 52 (5), pp. 1409-1412. Date of Electronic Publication: 2020 Mar 17.
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Typ publikacji:
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Case Reports; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: New York, N.Y. : Elsevier Science Inc.
Original Publication: New York Stratton.
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MeSH Terms:
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Chemical and Drug Induced Liver Injury/*etiology
Dietary Supplements/*adverse effects
Liver Failure, Acute/*chemically induced
Adult ; Chemical and Drug Induced Liver Injury/surgery ; Hepatic Encephalopathy/chemically induced ; Humans ; Liver Failure, Acute/surgery ; Liver Transplantation/methods ; Male
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Entry Date(s):
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Date Created: 20200321 Date Completed: 20201026 Latest Revision: 20201026
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Update Code:
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20240105
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DOI:
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10.1016/j.transproceed.2020.01.072
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PMID:
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32192741
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Acute liver failure is a rare condition consisting of abrupt and extensive hepatocyte injury, leading to significant liver dysfunction associated with a high mortality. Liver transplantation is the most effective treatment in severe cases. The most common cause of acute liver failure in Western countries is drug-induced liver injury caused by prescription drugs and herbal and dietary supplements. Thermogenics, or fat burners, are a category of dietary supplements that claim to increase the resting metabolic rate, leading to weight loss. There are previous reports of acute liver failure associated with specific thermogenic formulations. We report the case of a 36-year-old male patient who developed jaundice 7 days after he started taking a thermogenic dietary supplement (Thermo Gun), with progressive deterioration of hepatic function and development of hepatic encephalopathy 19 days after the beginning of the symptoms. He had a Model for End-Stage Liver Disease score of 38 and fulfilled 4 of the King's College Criteria for poor prognosis in patients with acute liver failure. He underwent liver transplantation, receiving a graft from a cadaveric donor, and is alive with good liver graft function 2 years after the transplant. No possible causes for acute liver injury were identified other than the use of the supplement, which contained N-acetyl-L-tyrosine; 1,3,7-trimenthylxanthine; white willow; and 1-hydroxypholedrine. We found no previous reports in the literature of acute liver failure associated with those particular substances. This manuscript is compliant with the Helsinki Congress and the Istanbul Declaration.
(Copyright © 2020 Elsevier Inc. All rights reserved.)