Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood.

Szczegóły
Abstrakt

Tytuł:: Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood.
Autorzy:: Weeks O; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Bossé GD; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA.
Oderberg IM; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Akle S; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.
Houvras Y; Department of Surgery and.; Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
Wrighton PJ; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
LaBella K; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Iversen I; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Tavakoli S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Adatto I; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Schwartz A; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kloosterman D; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Tsomides A; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Charness ME; Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts, USA.; Neurology, Harvard Medical School, Boston, Massachusetts, USA.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Peterson RT; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA.
Steinhauser ML; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
Fazeli PK; Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Goessling W; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.; Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.; Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA.; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Źródło:: The Journal of clinical investigation [J Clin Invest] 2020 May 01; Vol. 130 (5), pp. 2252-2269.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
Original Publication: New Haven [etc.] American Society for Clinical Investigation.
MeSH Terms:: Diabetes Mellitus, Type 2*/etiology
Diabetes Mellitus, Type 2*/metabolism
Diabetes Mellitus, Type 2*/pathology
Fetal Alcohol Spectrum Disorders*/metabolism
Fetal Alcohol Spectrum Disorders*/pathology
Obesity*/etiology
Obesity*/metabolism
Obesity*/pathology
Prenatal Exposure Delayed Effects*/metabolism
Prenatal Exposure Delayed Effects*/pathology
Adult ; Animals ; Female ; Humans ; Infant, Newborn ; Intra-Abdominal Fat/metabolism ; Intra-Abdominal Fat/pathology ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Transgenic ; Pregnancy ; Registries ; Zebrafish
References:: Int J Obes (Lond). 2013 Aug;37(8):1051-7. (PMID: 23229735)
Public Health Nutr. 2011 Jan;14(1):119-26. (PMID: 20587115)
Congenit Anom (Kyoto). 2017 Nov;57(6):178-183. (PMID: 27859643)
Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):90-3. (PMID: 18226060)
Endocrinology. 2003 Feb;144(2):500-8. (PMID: 12538610)
Teratology. 1983 Apr;27(2):231-43. (PMID: 6867945)
Toxicol Lett. 2014 Apr 7;226(1):98-105. (PMID: 24472613)
J Pediatr (Rio J). 2007 Nov-Dec;83(6):494-504. (PMID: 18074050)
EMBO J. 2018 Nov 15;37(22):. (PMID: 30348863)
Sci Rep. 2015 Dec 03;5:17679. (PMID: 26631430)
J Neurosci Methods. 2012 Sep 30;210(2):266-71. (PMID: 22884772)
Gastroenterology. 2014 Mar;146(3):776-88. (PMID: 24148620)
Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E694-E704. (PMID: 29089335)
Addict Biol. 2019 Sep;24(5):898-907. (PMID: 30178621)
Pediatrics. 2014 Nov;134(5):855-66. (PMID: 25349310)
Gastroenterology. 2019 May;156(6):1788-1804.e13. (PMID: 30641053)
BMC Bioinformatics. 2009 Feb 03;10:48. (PMID: 19192299)
Nat Protoc. 2009;4(1):44-57. (PMID: 19131956)
Behav Brain Res. 2019 Jan 1;356:46-50. (PMID: 30107225)
Pediatrics. 2016 Aug;138(2):. (PMID: 27464676)
Gastroenterology. 2011 Oct;141(4):1404-11, 1411.e1-2. (PMID: 21726512)
Nutr Diabetes. 2012 Dec 17;2:e57. (PMID: 23247731)
PLoS Comput Biol. 2007 Mar 23;3(3):e39. (PMID: 17381235)
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Mar 8;97:109774. (PMID: 31655157)
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Dec 3;55:94-100. (PMID: 24690524)
Korean J Pediatr. 2016 Jan;59(1):1-7. (PMID: 26893597)
Behav Brain Res. 2009 Dec 14;205(1):38-44. (PMID: 19540270)
Endocrinology. 2013 Apr;154(4):1476-87. (PMID: 23456361)
Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792)
Dev Biol. 2016 Oct 1;418(1):108-123. (PMID: 27474396)
Lancet Glob Health. 2017 Mar;5(3):e290-e299. (PMID: 28089487)
Alcohol Alcohol Suppl. 1987;1:125-32. (PMID: 3322304)
Int J Obes (Lond). 2016 Sep;40(9):1452-60. (PMID: 27146467)
J Clin Endocrinol Metab. 2012 Aug;97(8):2637-43. (PMID: 22564668)
Lancet. 1985 Jul 13;2(8446):85-91. (PMID: 2861535)
Dev Disabil Res Rev. 2009;15(3):176-92. (PMID: 19731384)
Alcohol Clin Exp Res. 2014 Sep;38(9):2502-8. (PMID: 25159809)
BMC Bioinformatics. 2009 May 27;10:161. (PMID: 19473525)
FASEB J. 2015 Jul;29(7):2690-701. (PMID: 25733565)
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16757-8. (PMID: 20855592)
Sci Rep. 2017 Nov 27;7(1):16362. (PMID: 29180630)
Pediatr Endocrinol Rev. 2008 Dec;6(2):241-7. (PMID: 19202511)
Alcohol. 2014 Sep;48(6):595-602. (PMID: 25012627)
Nature. 2005 Jul 21;436(7049):356-62. (PMID: 16034410)
Environ Pollut. 2015 Nov;206:275-81. (PMID: 26204572)
Diabetes. 2017 Jan;66(1):58-63. (PMID: 27797907)
Cold Spring Harb Perspect Biol. 2012 Jun 01;4(6):. (PMID: 22535228)
Methods Cell Biol. 2011;105:63-86. (PMID: 21951526)
Natl Health Stat Report. 2008 Oct 22;(10):1-48. (PMID: 25585443)
Pediatrics. 2015 Nov;136(5):e1395-406. (PMID: 26482673)
Nat Protoc. 2008;3(1):59-69. (PMID: 18193022)
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517)
Am J Physiol Endocrinol Metab. 2000 Jul;279(1):E83-7. (PMID: 10893326)
Nat Protoc. 2010 Nov;5(11):1786-99. (PMID: 21030954)
Int J Endocrinol. 2011;2011:269853. (PMID: 22190925)
J Intern Med. 2004 Sep;256(3):254-9. (PMID: 15324369)
Sci Rep. 2015 Nov 19;5:16867. (PMID: 26581663)
Alcohol Clin Exp Res. 2014 Mar;38(3):871-8. (PMID: 24164456)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Birth Defects Res C Embryo Today. 2011 Mar;93(1):3-11. (PMID: 21425437)
J Intern Med. 2007 May;261(5):437-52. (PMID: 17444883)
Hepatology. 2018 Apr;67(4):1531-1545. (PMID: 29091294)
J Biol Chem. 2016 Aug 26;291(35):18536-46. (PMID: 27405764)
Curr Dev Disord Rep. 2015 Sep;2(3):219-227. (PMID: 26543794)
Toxicol Appl Pharmacol. 2014 Jan 15;274(2):263-73. (PMID: 24275070)
Development. 2013 Aug;140(15):3254-65. (PMID: 23861062)
Metabolism. 2003 Apr;52(4):454-62. (PMID: 12701058)
Int J Obes (Lond). 2015 May;39(5):734-41. (PMID: 25468829)
Nature. 2004 Jan 29;427(6973):411-2. (PMID: 14749819)
Semin Liver Dis. 2013 Nov;33(4):321-9. (PMID: 24222090)
Cell Metab. 2012 Aug 8;16(2):189-201. (PMID: 22863804)
J Am Soc Nephrol. 2010 Nov;21(11):1891-902. (PMID: 20829403)
J Proteome Res. 2013 Apr 5;12(4):1580-90. (PMID: 23413775)
J Clin Invest. 2002 Nov;110(10):1383-8. (PMID: 12438433)
Alcohol Clin Exp Res. 2019 Aug;43(8):1727-1733. (PMID: 31166027)
Lancet Neurol. 2019 Aug;18(8):760-770. (PMID: 31160204)
Nutr Rev. 2012 Nov;70(11):642-53. (PMID: 23110643)
Nature. 2013 Apr 25;496(7446):498-503. (PMID: 23594743)
Mech Dev. 2009 Oct;126(10):898-912. (PMID: 19595765)
J Pediatr. 2016 Feb;169:194-200.e1. (PMID: 26608087)
Mutat Res. 1979 Dec;65(4):229-59. (PMID: 117354)
Congenit Heart Dis. 2007 Jul-Aug;2(4):250-5. (PMID: 18377476)
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Sep;159(3):352-9. (PMID: 25916279)
Pediatrics. 2016 Aug;138(2):. (PMID: 27401098)
Neurotoxicol Teratol. 2017 May;61:66-73. (PMID: 28223149)
Obesity (Silver Spring). 2006 Aug;14(8):1330-43. (PMID: 16988075)
PLoS One. 2018 Jun 28;13(6):e0199213. (PMID: 29953483)
Diabetes. 2009 Nov;58(11):2565-73. (PMID: 19690063)
Dis Model Mech. 2017 Jun 1;10(6):797-809. (PMID: 28348140)
Behav Brain Res. 2008 Mar 17;188(1):168-77. (PMID: 18054804)
Cell Rep. 2017 Sep 19;20(12):2766-2774. (PMID: 28930673)
Grant Information:: R24 OD017870 United States OD NIH HHS; F32 AA025271 United States AA NIAAA NIH HHS; F32 AA027135 United States AA NIAAA NIH HHS; R01 DK105198 United States DK NIDDK NIH HHS; R01 DK090311 United States DK NIDDK NIH HHS; F31 AA025254 United States AA NIAAA NIH HHS
Contributed Indexing:: Keywords: Development; Embryonic development; Metabolism; Obesity
Entry Date(s):: Date Created: 20200324 Date Completed: 20210126 Latest Revision: 20240214
Update Code:: 20240214
PubMed Central ID:: PMC7190939
DOI:: 10.1172/JCI132139
PMID:: 32202514
: Czasopismo naukowe

Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there is no consensus on the implications of PAE on metabolic disease risk in adults. Here, we describe a cohort of adults with FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity. Using a zebrafish model for PAE, we performed population studies to elucidate the metabolic disease seen in the clinical cohort. Embryonic alcohol exposure (EAE) in male zebrafish increased the propensity for diet-induced obesity and fasting hyperglycemia in adulthood. We identified several consequences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptional changes. Taken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that behavioral changes and primary organ dysfunction contribute to resultant metabolic abnormalities.

Informacja