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Tytuł:
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Terpenes on Rhipicephalus (Boophilus) microplus: Acaricidal activity and acetylcholinesterase inhibition.
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Autorzy:
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Cardoso ADS; Laboratory of Plant Biochemistry, Federal University of Maranhão, Sao Luís, MA, Brazil.
Santos EGG; Laboratory of Plant Biochemistry, Federal University of Maranhão, Sao Luís, MA, Brazil.
Lima ADS; Laboratory of Parasite Control, Federal University of Maranhão, Sao Luís, MA, Brazil.
Temeyer KB; Knipling-Bushland U.S.Livestock Insects Research Laboratory, Kerrville, TX, United States.
Pérez de León AA; Knipling-Bushland U.S.Livestock Insects Research Laboratory, Kerrville, TX, United States.
Costa LM Junior; Laboratory of Parasite Control, Federal University of Maranhão, Sao Luís, MA, Brazil. Electronic address: .
Soares AMDS; Laboratory of Plant Biochemistry, Federal University of Maranhão, Sao Luís, MA, Brazil. Electronic address: .
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Źródło:
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Veterinary parasitology [Vet Parasitol] 2020 Apr; Vol. 280, pp. 109090. Date of Electronic Publication: 2020 Mar 19.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Amsterdam : Elsevier Scientific Pub. Co.
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MeSH Terms:
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Acaricides*
Cholinesterase Inhibitors*
Rhipicephalus*/growth & development
Terpenes*
Tick Control*
Animals ; Female ; Larva/growth & development
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Contributed Indexing:
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Keywords: Natural compound; Terpenes; Tick
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Substance Nomenclature:
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0 (Acaricides)
0 (Cholinesterase Inhibitors)
0 (Terpenes)
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Entry Date(s):
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Date Created: 20200326 Date Completed: 20201103 Latest Revision: 20201103
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Update Code:
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20240105
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DOI:
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10.1016/j.vetpar.2020.109090
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PMID:
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32208306
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The Rhipicephalus (Boophilus) microplus tick is the main ectoparasite of cattle in tropical and subtropical regions worldwide. Resistance to chemical acaricides has become widespread affirming the need for new drugs to tick control. Terpenes have become a promising alternative for cattle tick control, however the mechanism of action of these compounds is still controversial. Inhibition of acetylcholinesterase (AChE) is a well established mechanism of action of organophosphate and carbamate acaricides, but the possible action of terpenes on tick AChEs has seldom been studied in resistant and sensitive strains of R. (B.) microplus. The aim of the present study was to evaluate terpene inhibition of AChE from resistant and sensitive strains of R. (B.) microplus in correlation with their acaricidal activity. Among the terpenes used in the present study, p-cymene, thymol, carvacrol, and citral displayed acaricidal activity with LC 50 of 1.75, 1.54, 1.41, and 0.38 mg.mL -1 for the susceptible strain, and LC 50 of 1.40, 1.81, 1.10, and 1.13 mg.mL -1 for the resistant strain. Thymol and carvacrol inhibited the AChE of the susceptible strain larvae with IC 50 of 0.93 and 0.04 mg.mL -1 , respectively. The IC 50 exhibited by eucalyptol, carvacrol and thymol for AChE of the resistant strain larvae were 0.36, 0.28, and 0.13 mg.mL -1 , respectively. This was the first study to investigate the action of terpenes on AChE from susceptible and resistant R. (B.) microplus. As not all terpenes with acaridical activity showed AChE inhibition, the participation of AChE in the acaricidal activity of terpenes needs further investigation.
Competing Interests: Declaration of Competing Interest The authors declare that there is no conflict of interest regarding the publication of this article.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
