Non-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction.

Tytuł:: Non-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction.
Autorzy:: Clinton CM; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
Bain JR; Metabolomics Laboratory, Duke Molecular Physiology Institute, and Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Muehlbauer MJ; Duke Molecular Physiology Institute, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.
Li Y; Biostatistics and Computational Biology Branch, Intramural Research Program, National Institute of Environmental Health Sciences, Research, Triangle Park, NC, USA.
Li L; Biostatistics and Computational Biology Branch, Intramural Research Program, National Institute of Environmental Health Sciences, Research, Triangle Park, NC, USA.
O'Neal SK; Duke Molecular Physiology Institute, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.
Hughes BL; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
Cantonwine DE; Division of Maternal-Fetal Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mcelrath TF; Division of Maternal-Fetal Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ferguson KK; Epidemiology Branch, Intramural Research Program, National Institute of Environmental Health Sciences, Research, Triangle Park, NC, USA. .
Źródło:: Scientific reports [Sci Rep] 2020 Mar 24; Vol. 10 (1), pp. 5307. Date of Electronic Publication: 2020 Mar 24.
Typ publikacji:: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Metabolome*
Biomarkers/*urine
Fetal Growth Retardation/*diagnosis
Infant, Small for Gestational Age/*metabolism
Adult ; Birth Weight ; Case-Control Studies ; Female ; Fetal Growth Retardation/urine ; Gestational Age ; Humans ; Infant, Newborn ; Maternal Age ; Pregnancy
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Substance Nomenclature:: 0 (Biomarkers)
Entry Date(s):: Date Created: 20200327 Date Completed: 20201123 Latest Revision: 20210324
Update Code:: 20240105
PubMed Central ID:: PMC7093500
DOI:: 10.1038/s41598-020-62131-7
PMID:: 32210262
: Czasopismo naukowe

Pełny tekst

Our objective was to identify metabolites associated with fetal growth restriction (FGR) by examining early and late pregnancy differences in non-targeted urinary metabolites among FGR cases and non-FGR controls. An exploratory case-control study within LIFECODES birth cohort was performed. FGR cases (N = 30), defined as birthweight below the 10 th percentile, were matched with controls (N = 30) based on maternal age, race, pre-pregnancy body mass index, and gestational age at delivery. Gas chromatography/electron-ionization mass spectrometry was performed on urine samples collected at 10 and 26 weeks of gestation. Differences in urinary metabolite levels in cases and controls at each time point and between the two time points were calculated and then changes compared across pregnancy. 137 unique urinary metabolites were annotated, and several identified that were higher in cases compared to controls. For example, urinary concentrations of benzoic acid were higher in cases compared to controls at both study visits (3.01-fold higher in cases at visit 1, p < 0.01; 3.10-fold higher in cases at visit 3, p = 0.05). However, these findings from our exploratory analysis were not robust to false-discovery-rate adjustment. In conclusion, using a high-resolution, non-targeted approach, we found specific urinary organic acids differed over pregnancy by FGR case status.

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