Cell-intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg.

Tytuł:: Cell-intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg.
Autorzy:: van Teijlingen Bakker N; Department of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.; Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany.
Pearce EJ; Department of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany.; Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany.
Źródło:: Immunological reviews [Immunol Rev] 2020 May; Vol. 295 (1), pp. 54-67. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Język:: English
Imprint Name(s):: Publication: <2002-> : Oxford : Blackwell
Original Publication: Copenhagen, Munksgaard.
MeSH Terms:: Mononuclear Phagocyte System/*immunology
Mononuclear Phagocyte System/*metabolism
Phagocytes/*immunology
Phagocytes/*metabolism
Animals ; Energy Metabolism ; Humans ; Macrophage Activation/genetics ; Macrophage Activation/immunology ; Macrophages/cytology ; Macrophages/immunology ; Macrophages/metabolism ; Mononuclear Phagocyte System/cytology ; Phagocytes/cytology
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Grant Information:: R01 AI110481 United States AI NIAID NIH HHS; AI110481 United States NH NIH HHS
Contributed Indexing:: Keywords: IL-4; LPS; TCA cycle; alternative activation; cytokines; dendritic cells; glycolysis; immunometabolism; inflammation; macrophages; metabolism; mitochondria
Entry Date(s):: Date Created: 20200404 Date Completed: 20210603 Latest Revision: 20240305
Update Code:: 20240305
PubMed Central ID:: PMC10911050
DOI:: 10.1111/imr.12848
PMID:: 32242952
: Czasopismo naukowe

Pełny tekst

We have only recently started to appreciate the extent to which immune cell activation involves significant changes in cellular metabolism. We are now beginning to understand how commitment to specific metabolic pathways influences aspects of cellular biology that are the more usual focus of immunological studies, such as activation-induced changes in gene transcription, post-transcriptional regulation of transcription, post-translational modifications of proteins, cytokine secretion, etc. Here, we focus on metabolic reprogramming in mononuclear phagocytes downstream of stimulation with inflammatory signals (such as LPS and IFNγ) vs alternative activation signals (IL-4), with an emphasis on work on dendritic cells and macrophages from our laboratory, and related studies from others. We cover aspects of glycolysis and its branching pathways (glycogen synthesis, pentose phosphate, serine synthesis, hexose synthesis, and glycerol 3 phosphate shuttle), the tricarboxylic acid pathway, fatty acid synthesis and oxidation, and mitochondrial biology. Although our understanding of the metabolism of mononuclear phagocytes has progressed significantly over the last 10 years, major challenges remain, including understanding the effects of tissue residence on metabolic programming related to cellular activation, and the translatability of findings from mouse to human biology.
(© 2020 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.)

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