Adenosine kinase and adenosine receptors A <subscript>1</subscript> R and A <subscript>2A</subscript> R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP. - OpacWWW

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Tytuł:: Adenosine kinase and adenosine receptors A 1 R and A 2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.
Autorzy:: Patodia S; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; School of Cancer Sciences, University of Southampton, Southampton, UK.
Paradiso B; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; School of Cancer Sciences, University of Southampton, Southampton, UK.
Garcia M; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; School of Cancer Sciences, University of Southampton, Southampton, UK.
Ellis M; Neuropathology Division, National Hospital for Neurology and Neurosurgery, London, UK.
Diehl B; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; School of Cancer Sciences, University of Southampton, Southampton, UK.
Thom M; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; School of Cancer Sciences, University of Southampton, Southampton, UK.; Neuropathology Division, National Hospital for Neurology and Neurosurgery, London, UK.
Devinsky O; Langone Comprehensive Epilepsy Center, New York University, New York, New York.
Źródło:: Epilepsia [Epilepsia] 2020 Apr; Vol. 61 (4), pp. 787-797. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Publication: Malden, MA : Blackwell Science
Original Publication: Copenhagen : Munskgaard
MeSH Terms:: Sudden Unexpected Death in Epilepsy*/etiology
Sudden Unexpected Death in Epilepsy*/pathology
Adenosine Kinase/*metabolism
Epilepsy, Temporal Lobe/*metabolism
Receptor, Adenosine A1/*metabolism
Receptor, Adenosine A2A/*metabolism
Adult ; Epilepsy, Temporal Lobe/pathology ; Epilepsy, Temporal Lobe/physiopathology ; Female ; Hippocampus/pathology ; Humans ; Male ; Risk Factors ; Sclerosis/pathology
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Grant Information:: U01 NS090415 United States NS NINDS NIH HHS; U01 NS090405 United States NS NINDS NIH HHS; 5U01NS090415 United States NS NINDS NIH HHS
Contributed Indexing:: Keywords: adenosine kinase; adenosine receptors; amygdala; gliosis; temporal lobe epilepsy
Substance Nomenclature:: 0 (ADORA2A protein, human)
0 (Receptor, Adenosine A1)
0 (Receptor, Adenosine A2A)
EC 2.7.1.20 (Adenosine Kinase)
Entry Date(s):: Date Created: 20200404 Date Completed: 20201016 Latest Revision: 20210610
Update Code:: 20240105
DOI:: 10.1111/epi.16487
PMID:: 32243580
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Objective: The "adenosine hypothesis of SUDEP" (sudden unexpected death in epilepsy) predicts that a seizure-induced adenosine surge combined with impaired metabolic clearance can foster lethal apnea or cardiac arrest. Changes in adenosine receptor density and adenosine kinase (ADK) occur in surgical epilepsy patients. Our aim was to correlate the distribution of ADK and adenosine A 2A and A 1 receptors (A 2A R and A 1 R) in surgical tissue from patients with temporal lobe epilepsy and hippocampal sclerosis (TLE/HS) with SUDEP risk factors.
Methods: In 75 cases, patients were stratified into high-risk (n = 16), medium-risk (n = 11) and low-risk (n = 48) categories according to the frequency of generalized seizures before surgery. Using whole-slide scanning Definiens image analysis we quantified the labeling index (LI) for ADK, A 2A R, and A 1 R in seven regions of interest: temporal cortex, temporal lobe white matter, CA1, CA4, dentate gyrus, subiculum, and amygdala and relative to glial and neuronal densities with glial fibrillary acidic protein (GFAP) and neuronal nuclear antigen (NeuN).
Results: A 1 R showed predominant neuronal, A 2A R astroglial, and ADK nuclear labeling in all regions but with significant variation. Compared with the low-risk group, the high-risk group had significantly lower A 2A R LI in the temporal cortex. In HS cases with severe neuronal cell loss and gliosis predominantly in the CA1 and CA4 regions, significantly higher A 1 R was present in the amygdala in high-risk than in low-risk cases. There was no significant difference in neuronal loss or gliosis between the risk groups or differences for ADK labeling.
Significance: Reduced cortical A 2A R suggests glial dysfunction and impaired adenosine modulation in response to seizures in patients at higher risk for SUDEP. Increased neuronal A 1 R in the high-risk group could contribute to periictal amygdala dysfunction in SUDEP.
(© 2020 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy.)

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Adenosine kinase and adenosine receptors A 1 R and A 2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.