Full-term low birth weight infants have differentially hypermethylated DNA related to immune system and organ growth: a comparison with full-term normal birth weight infants.

Tytuł:: Full-term low birth weight infants have differentially hypermethylated DNA related to immune system and organ growth: a comparison with full-term normal birth weight infants.
Autorzy:: Hayashi I; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1, Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8551, Japan. .; Laboratory of Nutrition Education and Nutritional Physiology, Graduate School of Human Science and Environment, University of Hyogo, Himeji, Japan. .
Yamaguchi K; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1, Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8551, Japan.; Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sumitomo M; Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.; Tajima KOUNOTORI Perinatal Medical Center, Toyooka Hospital, Toyooka, Japan.
Takakura K; Department of Obstetrics and Gynecology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Nagai N; Laboratory of Nutrition Education and Nutritional Physiology, Graduate School of Human Science and Environment, University of Hyogo, Himeji, Japan.
Sakane N; Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1, Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8551, Japan.
Źródło:: BMC research notes [BMC Res Notes] 2020 Apr 03; Vol. 13 (1), pp. 199. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji:: Comparative Study; Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : Biomed Central, 2008.
MeSH Terms:: DNA Methylation*
Infant, Low Birth Weight*
Adult ; Epigenesis, Genetic ; Female ; Humans ; Infant, Newborn ; Japan ; Middle Aged ; Promoter Regions, Genetic ; Young Adult
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Grant Information:: JPI5H0Z90I the Japan Society for the Promotion of Science
Contributed Indexing:: Keywords: DNA methylation; Gene; Gene ontology (GO); Immune system; Low birth weight; Term infant
Entry Date(s):: Date Created: 20200405 Date Completed: 20200406 Latest Revision: 20200411
Update Code:: 20240105
PubMed Central ID:: PMC7126402
DOI:: 10.1186/s13104-020-04961-2
PMID:: 32245519
: Czasopismo naukowe

Pełny tekst

Objective: Low birth weight (LBW) is a major public health issue as it increases the risk of noncommunicable diseases throughout life. However, the genome-wide DNA methylation patterns of full-term LBW infants (FT-LBWs) are still unclear. This exploratory study aimed to analyze the DNA methylation differences in FT-LBWs compared with those in full-term normal birth weight infants (FT-NBWs) whose mothers were nonsmokers and had no complications. Initially, 702 Japanese women with singleton pregnancies were recruited. Of these, four FT-LBWs and five FT-NBWs were selected as references for DNA methylation analysis, and 862,260 CpGs were assessed using Illumina Infinium MethylationEPIC BeadChip. Gene ontology enrichment analysis was performed using DAVID v6.8 software to identify the biological functions of hyper- and hypomethylated DNA in FT-LBWs.
Results: 483 hyper-differentially methylated genes (DMGs) and 35 hypo-DMGs were identified in FT-LBW promoter regions. Hyper-DMGs were annotated to 11 biological processes; "macrophage differentiation" (e.g., CASP8), "apoptotic mitochondrial changes" (e.g., BH3), "nucleotide-excision repair" (e.g., HUS1), and "negative regulation of inflammatory response" (e.g., NLRP12 and SHARPIN). EREG was classified into "ovarian cumulus expansion" within the "organism growth and organization" category. Our data imply that LBW might be associated with epigenetic modifications, which regulate the immune system and cell maturation.

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