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Tytuł pozycji:

Small molecules, big effects: microbial metabolites in intestinal immunity.

Tytuł :
Small molecules, big effects: microbial metabolites in intestinal immunity.
Autorzy :
Glotfelty LG; Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania.; Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Wong AC; Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Levy M; Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania.
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Źródło :
American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2020 May 01; Vol. 318 (5), pp. G907-G911. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
Język :
English
Journal Info :
Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1547 (Electronic) Linking ISSN: 01931857 NLM ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Subsets: MEDLINE
Imprint Name(s) :
Original Publication: Bethesda, MD : American Physiological Society
MeSH Terms :
Gastrointestinal Microbiome*
Immunity, Innate*
Immunity, Mucosal*
Bacteria/*metabolism
Intestinal Mucosa/*microbiology
Animals ; Antibodies/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Bacteria/immunology ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/metabolism ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Neuroimmunomodulation ; Signal Transduction ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Grant Information :
DP2 AG067511 United States AG NIA NIH HHS; T32 DK007066 United States DK NIDDK NIH HHS
Contributed Indexing :
Keywords: intestinal immunity*; intestinal metabolites*; microbiome*
Substance Nomenclature :
0 (Antibodies)
0 (Inflammation Mediators)
Entry Date(s) :
Date Created: 20200407 Date Completed: 20200728 Latest Revision: 20200728
Update Code :
20200729
DOI :
10.1152/ajpgi.00263.2019
PMID :
32249590
Czasopismo naukowe
The mammalian intestine is host to a vast number of microbial organisms. The immune system must balance tolerance with innate and adaptive defense mechanisms to maintain homeostasis with the microbial community. Interestingly, microbial metabolites have been shown to play a role in shaping the host immune response, thus assisting with adaptations that have significant implications for human health and disease. New investigations have uncovered roles for metabolites in modulating almost every aspect of the immune system. In this minireview, we survey these recent findings, which taken together reveal nuanced interactions that we are just beginning to understand.

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