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Tytuł:
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Is there any correlation between HPV and early radioresponse before brachytherapy in cervix uteri carcinoma?
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Autorzy:
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Yılmaz BD; Department of Radiation Oncology, Okmeydani Training and Research Hospital, İstanbul, Turkey. .
Uysal E; Department of Radiation Oncology, Okmeydani Training and Research Hospital, İstanbul, Turkey.
Gurdal N; Department of Radiation Oncology, Okmeydani Training and Research Hospital, İstanbul, Turkey.
Ozkan A; Department of Radiation Oncology, İstanbul Oncology Hospital, İstanbul, Turkey.
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Źródło:
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La Radiologia medica [Radiol Med] 2020 Oct; Vol. 125 (10), pp. 981-989. Date of Electronic Publication: 2020 Apr 10.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Milan : Springer Milan
Original Publication: Torino [etc.] Minerva medica.
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MeSH Terms:
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Brachytherapy*
Papillomaviridae*
Chemoradiotherapy/*methods
Uterine Cervical Neoplasms/*therapy
Aged ; Aged, 80 and over ; Female ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging/methods ; Middle Aged ; Positron-Emission Tomography ; Prognosis ; Radiopharmaceuticals ; Retrospective Studies ; Survival Rate ; Treatment Outcome ; Tumor Burden ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/virology
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Grant Information:
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APDP-TROD-2019-2 Turkish Society for Radiation Oncology
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Contributed Indexing:
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Keywords: Brachytherapy; HPV; Local advanced cervical cancer; Residual volume
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Substance Nomenclature:
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0 (Radiopharmaceuticals)
0Z5B2CJX4D (Fluorodeoxyglucose F18)
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Entry Date(s):
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Date Created: 20200412 Date Completed: 20200909 Latest Revision: 20200909
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Update Code:
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20240105
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DOI:
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10.1007/s11547-020-01187-x
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PMID:
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32277333
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Objective: The prognostic effect of human papilloma virus (HPV) on early radioresponse before brachytherapy was evaluated in locally advanced cervix uteri carcinoma patients.
Methods: Between 2015 and 2018, 150 patients with locally advanced carcinoma of the cervix uteri from University of Health Sciences Okmeydani Training and Research Hospital and Istanbul Oncology Hospital underwent chemotherapy concomitant with external radiotherapy and brachytherapy after performing fluorodeoxyglucose positron emission tomography (FDG PET) and magnetic resonance imaging (MRI) for purposes of staging and treatment planning. The treatment results of patients analyzed retrospectively.
Results: The median age of 57 patients was 53 years, and the initial tumor volume was 27 cm 3 . The median follow-up period was 22 months. The median tumor volume after external radiotherapy was significantly higher in patients without local control than those who responded to external radiotherapy (p = 0.031). The mean tumor diameter and volume in all HPV-negative patients after external radiotherapy were significantly higher than those of HPV-positive patients (p = 0.011 and p = 0.046, respectively). In a group of patients with poor early responses, local disease control could not be achieved despite the use of recommended higher doses of brachytherapy.
Conclusion: We could not determine the correlation between HPV contamination and patients who had early response intervention. But residual tumor of more than 2 cm in diameter after external radiotherapy may be a predictor of failed local control and development of metastasis within a short time.