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Tytuł:
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Octenyl-succinylated inulin for the encapsulation and release of hydrophobic compounds.
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Autorzy:
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Han L; Key Lab of Biotechnology and Bioresources Utilization of Ministry of Education, College of Life Science, Dalian Minzu University, Dalian, Liaoning, 116600, China; Glyn O. Phillips Hydrocolloid Research Centre at HBUT, School of Food and Biological Engineering, Hubei University of Technology, Wuhan, 430068, China.
Hu B; Glyn O. Phillips Hydrocolloid Research Centre at HBUT, School of Food and Biological Engineering, Hubei University of Technology, Wuhan, 430068, China.
Ratcliffe I; Centre for Water Soluble Polymers, Applied Science, Faculty of Arts, Science and Technology, Wrexham Glyndwr University, Plas Coch, Mold Road, Wrexham, LL11 2AW, United Kingdom.
Senan C; Centre for Water Soluble Polymers, Applied Science, Faculty of Arts, Science and Technology, Wrexham Glyndwr University, Plas Coch, Mold Road, Wrexham, LL11 2AW, United Kingdom.
Yang J; Centre for Water Soluble Polymers, Applied Science, Faculty of Arts, Science and Technology, Wrexham Glyndwr University, Plas Coch, Mold Road, Wrexham, LL11 2AW, United Kingdom.
Williams PA; Centre for Water Soluble Polymers, Applied Science, Faculty of Arts, Science and Technology, Wrexham Glyndwr University, Plas Coch, Mold Road, Wrexham, LL11 2AW, United Kingdom. Electronic address: .
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Źródło:
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Carbohydrate polymers [Carbohydr Polym] 2020 Jun 15; Vol. 238, pp. 116199. Date of Electronic Publication: 2020 Mar 21.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <1992-> : Barking : Elsevier Applied Science Publishers
Original Publication: London [Eng.] : Applied Science Publishers, c1981-
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MeSH Terms:
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Delayed-Action Preparations*/chemical synthesis
Delayed-Action Preparations*/chemistry
Drug Carriers*/chemical synthesis
Drug Carriers*/chemistry
Inulin/*chemistry
Starch/*analogs & derivatives
Micelles ; Starch/chemical synthesis ; Starch/chemistry ; beta Carotene
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Contributed Indexing:
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Keywords: Beta-carotene; Critical aggregation concentration; Encapsulation; Octenyl-succinylated inulin
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Substance Nomenclature:
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0 (Delayed-Action Preparations)
0 (Drug Carriers)
0 (Micelles)
0 (octenyl succinic anhydride-modified starch)
01YAE03M7J (beta Carotene)
9005-25-8 (Starch)
9005-80-5 (Inulin)
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Entry Date(s):
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Date Created: 20200418 Date Completed: 20210106 Latest Revision: 20210106
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Update Code:
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20240104
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DOI:
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10.1016/j.carbpol.2020.116199
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PMID:
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32299569
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Octenyl-succinylated inulins (OSA-inulin) were synthesized in aqueous solutions using inulin with varying degrees of polymerization (DP). They were characterized using 1 H NMR and FTIR and their degrees of substitution were determined. All the samples formed micellar aggregates in aqueous solution above a critical aggregation concentration (CAC) and solubilized beta-carotene. The amount of beta carotene solubilized within the micelles ranged from 12 to 25 mg/g of OSA-inulin and depended on the inulin molar mass. Dynamic light scattering showed that the aggregates, with and without dissolved beta-carotene, were ∼10-15 nm in size and this was confirmed by Transmission Electron Microscopy which also indicated that the micelles had a globular shape. OSA-inulin particles containing encapsulated beta-carotene were produced by freeze-drying. The encapsulated beta-carotene was not released from the freeze-dried particles when introduced into simulated gastric fluid at pH 2.5 but was readily released in simulated small intestinal fluid at pH 7. The results demonstrate the potential application of OSA-inulin in the encapsulation, dissolution and targeted delivery of hydrophobic drug molecules for nutraceutical, pharmaceutical and medical applications.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
