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Tytuł:
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Acidic conditions enhance the removal of sulfonamide antibiotics and antibiotic resistance determinants in swine manure.
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Autorzy:
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Lin H; The Institute of Environment, Resources, Soil and Fertilizers, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China.
Sun W; The Institute of Environment, Resources, Soil and Fertilizers, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China.
Yu Q; The Institute of Environment, Resources, Soil and Fertilizers, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China.
Ma J; The Institute of Environment, Resources, Soil and Fertilizers, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China. Electronic address: .
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Źródło:
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Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2020 Aug; Vol. 263 (Pt A), pp. 114439. Date of Electronic Publication: 2020 Mar 26.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987-
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MeSH Terms:
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Manure*
Anti-Bacterial Agents/*pharmacology
Animals ; Drug Resistance, Microbial/drug effects ; Genes, Bacterial/drug effects ; Soil Microbiology ; Sulfanilamide ; Sulfonamides ; Swine
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Contributed Indexing:
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Keywords: Antibiotic degradation; Antibiotic resistance genes; Antibiotic-resistant bacteria; Manure; pH
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
0 (Manure)
0 (Sulfonamides)
21240MF57M (Sulfanilamide)
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Entry Date(s):
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Date Created: 20200418 Date Completed: 20200710 Latest Revision: 20200710
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Update Code:
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20240104
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DOI:
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10.1016/j.envpol.2020.114439
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PMID:
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32302890
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Manure pH may vary depending on its inherent composition or additive contents. However, the effect of pH on the fate of antibiotics and antibiotic resistance determinants in manure remains unclear. This work demonstrated that pH adjustment promoted the removal of different sulfonamide antibiotics (SAs) within swine manure under incubation conditions, which increased from 26-60.8% to 75.0-86.0% by adjusting the initial pH from neutral (7.4) to acidic (5.4-4.8). Acidification was also demonstrated to inhibit the accumulation of antibiotic resistance genes in manure during incubation. Acidified manure contained both lower absolute and relative abundances of sul1 and sul2 than those at a neutral pH like 7.4. Further investigation indicated that acidification promoted the reduction of sul genes in manure by restricting sulfonamide-resistant bacteria (SRB) proliferation and inhibiting IntI1 accumulation. Furthermore, pH adjustment significantly influenced the composition of the manure bacterial community after incubation, which increased Firmicutes and decreased Proteobacteria. Close relationships were observed between pH-induced enrichment of the Firmicutes bacterial phylum, enhanced SAs degradation, and the fates of antibiotic resistance determinants. Overall, lowering the pH of manure promotes the degradation of SAs, decreases sul genes and SRB, and inhibits horizontal sul gene transfer, which could be a simple yet highly-effective manure management option to reduce antibiotic resistance.
Competing Interests: Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
