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Tytuł:
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A Meta-Analysis of Abnormal Glucose Metabolism in First-Episode Drug-Naive Schizophrenia.
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Autorzy:
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Yang W; Department of Pharmacy, TongDe Hospital of Zhejiang Province, 234 Gucui Rode, Hangzhou, 310012, China.
Zheng L
Zheng B
Zeng S
Li J
Liang B
Zhu J
Zhang M
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Źródło:
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Psychiatria Danubina [Psychiatr Danub] 2020 Spring; Vol. 32 (1), pp. 46-54.
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Typ publikacji:
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Journal Article; Meta-Analysis
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Język:
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English
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Imprint Name(s):
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Original Publication: Zagreb : Facultas Universitatis [i.e. Facultas Medica Universitatis] Studiorum Zagrabiensis in cooperation with WHO Collaborating Centre for Research and Training in Mental Health--KBC Zagreb, on behalf of the Danube Symposion of Psychiatry, 1989-
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MeSH Terms:
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Glucose/*metabolism
Schizophrenia/*metabolism
Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Insulin/blood ; Insulin/metabolism ; Schizophrenia/blood ; Schizophrenia/complications ; Schizophrenia/drug therapy
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Substance Nomenclature:
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0 (Blood Glucose)
0 (Insulin)
IY9XDZ35W2 (Glucose)
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Entry Date(s):
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Date Created: 20200418 Date Completed: 20200422 Latest Revision: 20200422
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Update Code:
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20240104
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DOI:
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10.24869/psyd.2020.46
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PMID:
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32303029
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Background: Patients with schizophrenia exhibit a higher mortality rate compared with the general population. This mortality has been attributed predominantly by the high risk of type 2 diabetes mellitus in the patients. We aimed to assess the inherent risk of glucose metabolism abnormalities in first-episode drug-naive schizophrenia.
Subjects and Methods: We searched English database (PubMed, EMBASE, MEDLINE, Cochrane Library databases) and Chinese database (Wan Fang Data, CBM disc, VIP, and CNKI) from their inception until Jul 2018 for case-control studies examining glucose metabolism abnormalities. Measurements, such as fasting plasma glucose levels, fasting plasma insulin levels, insulin resistance and HbA1c levels in first-episode antipsychotic-naive patients were used to test for prediabetes. Standardized/weighted mean differences and 95% confidence intervals were calculated and analyzed.
Results: 19 studies (13 in English and 6 in Chinese) consisting of 1065 patients and 873 controls were included. Fasting plasma glucose levels (95% CI; 0.02 to 0.29; P=0.03), 2 h plasma glucose levels after an OGTT (95% CI; 0.63 to 1.2; P<0.00001), fasting plasma insulin levels (95% CI; 0.33 to 0.73; P<0.00001), insulin resistance (95% CI; 0.29 to 0.6; P<0.00001) in patients with first-episode schizophrenia were significant elevated. There was no significant difference in HbA1c level (95% CI; -0.34 to 0.18; P=0.54) in patients with first-episode schizophrenia compared with controls.
Conclusions: This meta-analysis showed that glucose metabolism was impaired in patients with first-episode schizophrenia. Higher quality studies with larger samples are warranted to confirm these findings.