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Tytuł pozycji:

Validation of semi-automated flow-mediated dilation measurement in healthy volunteers.

Tytuł:
Validation of semi-automated flow-mediated dilation measurement in healthy volunteers.
Autorzy:
Dobbie LJ; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Mackin ST; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Hogarth K; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Lonergan F; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Kannenkeril D; Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Germany.
Brooksbank K; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Delles C; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Źródło:
Blood pressure monitoring [Blood Press Monit] 2020 Aug; Vol. 25 (4), pp. 216-223.
Typ publikacji:
Journal Article; Validation Study
Język:
English
Imprint Name(s):
Publication: <2000->: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: London ; Philadelphia, PA : Rapid Science Publishers, c1996-
MeSH Terms:
Brachial Artery*/diagnostic imaging
Dilatation*
Automation ; Healthy Volunteers ; Humans ; Observer Variation ; Reproducibility of Results
References:
Vasc Med. 2012 Apr;17(2):79-84. (PMID: 22402933)
J Chiropr Med. 2016 Jun;15(2):155-63. (PMID: 27330520)
J Atheroscler Thromb. 2013;20(1):1-8. (PMID: 22972428)
Heart. 2013 Dec;99(24):1837-42. (PMID: 24153417)
Eur Heart J. 2013 Dec;34(45):3501-7. (PMID: 23821401)
Circulation. 2012 Aug 7;126(6):753-67. (PMID: 22869857)
N Engl J Med. 1993 Dec 30;329(27):2002-12. (PMID: 7504210)
Atherosclerosis. 2016 May;248:196-202. (PMID: 27023841)
Int J Impot Res. 2010 Mar-Apr;22(2):77-90. (PMID: 20032988)
J Am Coll Cardiol. 2002 Jan 16;39(2):257-65. (PMID: 11788217)
Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H2-12. (PMID: 20952670)
Atherosclerosis. 2015 Oct;242(2):433-42. (PMID: 26291496)
Microvasc Res. 2018 May;117:50-56. (PMID: 29338981)
Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1109-16. (PMID: 19633208)
J Hypertens. 2016 Sep;34(9):1738-45. (PMID: 27488550)
Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H985-1002. (PMID: 16632549)
Circulation. 2007 May 8;115(18):2390-7. (PMID: 17452608)
Entry Date(s):
Date Created: 20200419 Date Completed: 20201208 Latest Revision: 20221005
Update Code:
20240104
PubMed Central ID:
PMC7331823
DOI:
10.1097/MBP.0000000000000448
PMID:
32304385
Czasopismo naukowe
Background: Flow-mediated dilation (FMD) is a non-invasive imaging modality used to measure endothelial function but has significant intra- and inter-observer variability. The use of semi-automated FMD devices could overcome this limitation. We assessed the reproducibility of same-day semi-automated FMD measurements by investigators who received basic training on the correct use of the device.
Methods: Forty-three healthy volunteers had two brachial artery FMD measurements performed 20 minutes apart using the UNEX EF 38G device, and automated outputs were produced. Images were also manually analysed using edge-detection software. The reproducibility of repeat FMD measurements within individuals was compared for automated and manual readings, and the correlation between analytical techniques was calculated.
Results: Twenty-five percent of scans were of non-diagnostic quality (n = 32). Automated analyses demonstrated sub-optimal reproducibility and measurement variability [intraclass correlation coefficient (ICCC) = 0.334, coefficient of variation (CV) = 45.87%]. In contrast, manually analysed scans had excellent reproducibility and low measurement variance (ICCC = 0.815, CV = 11.40%). FMD values obtained from automated and manual analysis correlated poorly (r = 0.164), whereas resting (r = 0.955) and maximal brachial artery diameters demonstrated excellent correlation (r = 0.867).
Conclusion: Manually evaluated serial UNEX EF readings have good reproducibility and therefore, the optimal FMD workflow involves manual analyses prior to independent automated interrogation. The high non-diagnostic scan rate is most likely the result of insufficient training and indicates that semi-automatic devices such as UNEX EF should be used by experienced investigators to achieve optimal results.

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