The microbial flora of clinically infected cutaneous metastases: a retrospective study.

Tytuł:: The microbial flora of clinically infected cutaneous metastases: a retrospective study.
Autorzy:: Virgen CA; Department of Dermatology, University of California Irvine, Irvine, USA.
Barker CA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA.
Lacouture ME; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.
Źródło:: Clinical and experimental dermatology [Clin Exp Dermatol] 2020 Aug; Vol. 45 (6), pp. 722-726. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2023- : Oxford : Oxford University Press
Original Publication: Oxford : Blackwell Scientific Publications.
MeSH Terms:: Anti-Bacterial Agents/*administration & dosage
Gram-Negative Bacteria/*isolation & purification
Gram-Positive Bacteria/*isolation & purification
Skin/*microbiology
Skin Diseases, Bacterial/*drug therapy
Skin Neoplasms/*microbiology
Skin Neoplasms/*secondary
Administration, Oral ; Administration, Topical ; Aspergillus flavus/isolation & purification ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Skin Diseases, Bacterial/etiology ; Skin Neoplasms/complications
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Grant Information:: P30 CA008748 United States CA NCI NIH HHS; American Academy of Dermatology; T32-GM007198 United States NH NIH HHS; RJR Oncodermatology Fund; P30-CA008748 United States NH NIH HHS; T32 GM007198 United States GM NIGMS NIH HHS
Substance Nomenclature:: 0 (Anti-Bacterial Agents)
Entry Date(s):: Date Created: 20200419 Date Completed: 20200731 Latest Revision: 20210802
Update Code:: 20240104
PubMed Central ID:: PMC7363576
DOI:: 10.1111/ced.14241
PMID:: 32304588
: Czasopismo naukowe

Pełny tekst

Symptomatic cutaneous metastases are associated with discharge, malodour, pruritus and pain, all of which may negatively impact quality of life and cutaneous health. We conducted a retrospective chart review of patients referred to the Dermatology Service at Memorial Sloan Kettering Cancer Center between August 2006 and June 2015, and characterized the microbial flora and antimicrobial management of cutaneous metastases in 64 patients. We detected pathogenic and/or opportunistic bacteria in 50% of skin lesions. The most commonly isolated organisms were Staphylococcus aureus and Pseudomonas aeruginosa. Patients treated with oral antibiotics, alone or in combination with topical agents, had a statistically significant better improvement in infectious symptoms than those treated without oral antibiotics. Our findings suggest that the normal skin microbial flora is disrupted in patients with symptomatic skin metastases. Oral antibiotics may provide benefit when used as first-line therapy for infected skin lesions in patients with symptomatic cutaneous metastases.
(© 2020 British Association of Dermatologists.)

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