-
Tytuł:
-
Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography.
-
Autorzy:
-
Tzolos E; Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
McElhinney P; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Williams MC; BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, UK.
Cadet S; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Dweck MR; BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, UK.
Berman DS; Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Slomka PJ; Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Newby DE; BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, UK.
Dey D; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: .
-
Źródło:
-
Journal of cardiovascular computed tomography [J Cardiovasc Comput Tomogr] 2021 Jan-Feb; Vol. 15 (1), pp. 81-84. Date of Electronic Publication: 2020 Apr 14.
-
Typ publikacji:
-
Clinical Trial; Journal Article; Multicenter Study
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: Cambridge, MA : Elsevier
-
MeSH Terms:
-
Computed Tomography Angiography*
Coronary Angiography*
Multidetector Computed Tomography*
Plaque, Atherosclerotic*
Adipose Tissue/*diagnostic imaging
Coronary Artery Disease/*diagnostic imaging
Coronary Vessels/*diagnostic imaging
Female ; Heart Disease Risk Factors ; Humans ; Male ; Middle Aged ; Observer Variation ; Predictive Value of Tests ; Reproducibility of Results ; Risk Assessment ; Scotland ; Severity of Illness Index
-
References:
-
Eur Radiol. 2014 Sep;24(9):2300-8. (PMID: 24962824)
J Cardiovasc Comput Tomogr. 2009 Nov-Dec;3(6):372-82. (PMID: 20083056)
Lancet. 2015 Jun 13;385(9985):2383-91. (PMID: 25788230)
N Engl J Med. 2018 Sep 06;379(10):924-933. (PMID: 30145934)
Circ Cardiovasc Imaging. 2014 Jul;7(4):629-38. (PMID: 24906356)
Radiology. 2010 Nov;257(2):516-22. (PMID: 20829536)
Eur Heart J Cardiovasc Imaging. 2017 Dec 1;18(12):1331-1339. (PMID: 28950315)
Eur Radiol. 2019 Nov;29(11):6129-6139. (PMID: 31028446)
J Cardiovasc Comput Tomogr. 2016 Mar-Apr;10(2):114-20. (PMID: 26712694)
J Am Coll Cardiol. 2016 Apr 19;67(15):1759-1768. (PMID: 27081014)
Trials. 2012 Oct 04;13:184. (PMID: 23036114)
J Am Coll Cardiol. 2018 Jun 5;71(22):2511-2522. (PMID: 29852975)
Eur Heart J Cardiovasc Imaging. 2019 Jun 1;20(6):636-643. (PMID: 30789223)
-
Grant Information:
-
CH/09/002/26360 United Kingdom BHF_ British Heart Foundation; FS/ICRF/20/26002 United Kingdom BHF_ British Heart Foundation; R01 HL133616 United States HL NHLBI NIH HHS; R01 HL148787 United States HL NHLBI NIH HHS
-
Contributed Indexing:
-
Keywords: Computed tomography angiography; Coronary artery disease; Non-calcified plaque; Pericoronary adipose tissue; Repeatability
-
Entry Date(s):
-
Date Created: 20200422 Date Completed: 20210406 Latest Revision: 20230924
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC7554067
-
DOI:
-
10.1016/j.jcct.2020.03.007
-
PMID:
-
32312662
-
Background: High pericoronary adipose tissue (PCAT) attenuation and non-calcified plaque burden (NCP) measured from coronary CT angiography (CTA) have been implicated in future cardiac events. We aimed to evaluate the interobserver and intraobserver repeatability of PCAT attenuation and NCP burden measurement from CTA, in a sub-study of the prospective SCOT-HEART trial.
Methods: Fifty consecutive CTAs from participants of the CT arm of the prospective SCOT-HEART trial were included. Two experienced observers independently measured PCAT attenuation and plaque characteristics throughout the whole coronary tree from CTA using semi-automatic quantitative software.
Results: We analyzed proximal segments in 157 vessels. Intraobserver mean differences in PCAT attenuation and NCP plaque burden were -0.05HU and 0.92% with limits of agreement (LOA) of ±1.54 and ± 5.97%. Intraobserver intraclass correlation coefficients (ICC) for PCAT attenuation and NCP burden were excellent (0.999 and 0.978). Interobserver mean differences in PCAT attenuation and NCP plaque burden were 0.13HU [LOA ±1.67HU] and -0.23% (LOA ±9.61%). Interobserver ICC values for PCAT attenuation and NCP burden were excellent (0.998 and 0.944).
Conclusion: PCAT attenuation and NCP burden on CTA has high intraobserver and interobserver repeatability, suggesting they represent a repeatable and robust method of quantifying cardiovascular risk.
Competing Interests: Declaration of competing interest Outside the current study, D.D., S.C., D.S., P.S. received software royalties from Cedars-Sinai Medical Center; D.D., D.S. P.S. hold a patent.
(Copyright © 2020 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.)
