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Tytuł pozycji:

Discohesive growth pattern (Disco-p) as an unfavorable prognostic factor in lung adenocarcinoma: an analysis of 1062 Japanese patients with resected lung adenocarcinoma.

Tytuł:
Discohesive growth pattern (Disco-p) as an unfavorable prognostic factor in lung adenocarcinoma: an analysis of 1062 Japanese patients with resected lung adenocarcinoma.
Autorzy:
Rokutan-Kurata M; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Yoshizawa A; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan. .
Nakajima N; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Teramoto Y; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Sumiyoshi S; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Kondo K; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Hamaji M; Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan.
Sonobe M; Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan.; Department of Thoracic Surgery, Osaka Red Cross Hospital, Osaka, Japan.
Menju T; Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan.
Date H; Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan.
Haga H; Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Źródło:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2020 Sep; Vol. 33 (9), pp. 1722-1731. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 2023- : [New York] : Elsevier Inc.
Original Publication: Baltimore, MD : Williams & Wilkins, c1988-
MeSH Terms:
Adenocarcinoma of Lung/*pathology
Lung/*pathology
Lung Neoplasms/*pathology
Lymphatic Metastasis/*pathology
Adenocarcinoma of Lung/mortality ; Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Female ; Humans ; Japan ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Sex Factors ; Survival Rate ; Young Adult
References:
Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG (eds). WHO classification of tumours of the lung, pleura, thymus and heart. 4th ed. Lyon: International Agency for Research on Cancer; 2015.
Warth A, Muley T, Kossakowski C, Stenzinger A, Schirmacher P, Dienemann H, et al. Prognostic impact and clinicopathological correlations of the cribriform pattern in pulmonary adenocarcinoma. J Thorac Oncol. 2015;10:638–44. (PMID: 10.1097/JTO.0000000000000490)
Tsuta K, Ishii G, Yoh K, Nitadori J, Hasebe T, Nishiwaki Y, et al. Primary lung carcinoma with signet-ring cell carcinoma components: clinicopathological analysis of 39 cases. Am J Surg Pathol. 2004;28:868–74. (PMID: 10.1097/00000478-200407000-00004)
Minami Y, Iijima T, Onizuka M, Sakakibara Y, Noguchi M. Pulmonary adenocarcinoma with massive lymphocyte infiltration: report of three cases. Lung Cancer. 2003;42:63–8. (PMID: 10.1016/S0169-5002(03)00281-2)
Kadota K, Yeh YC, Villena-Vargas J, Cherkassky L, Dril EN, Sima CS, et al. Tumor budding correlates with the protumor immune microenvironment and is an independent prognostic factor for recurrence of stage I lung adenocarcinoma. Chest. 2015;148:711–21. (PMID: 10.1378/chest.14-3005)
Odze RD, Montgomery EA, Wang HH, Lauwers GY, Greenson JK, Carneiro F, et al. Tumor of the esophagus and stomach. In: AFIP atlas of tumor pathology, 4th series, fascicle 28. Arlington, VA: American Registry of Pathology; 2019.
Fukayama M, Rugge M, Washington M. Tumours of the stomach. In: WHO classification of tumours of the digestive system. 5th ed. Lyon: International Agency for Research on Cancer; 2019. p. 60–110.
Mariette C, Carneiro F, Grabsch HI, van der Post RS, Allum W, de Manzoni G, et al. Consensus on the pathological definition and classification of poorly cohesive gastric carcinoma. Gastric Cancer. 2019;22:1–9. (PMID: 10.1007/s10120-018-0868-0)
Ueno H, Murphy J, Jass JR, Mochizuki H, Talbot IC. Tumour ‘budding’ as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology. 2002;40:127–32. (PMID: 10.1046/j.1365-2559.2002.01324.x)
Kawachi H, Eishi Y, Ueno H, Nemoto T, Fujimori T, Iwashita A, et al. A three-tier classification system based on the depth of submucosal invasion and budding/sprouting can improve the treatment strategy for T1 colorectal cancer: a retrospective multicenter study. Mod Pathol. 2015;28:872–9. (PMID: 10.1038/modpathol.2015.36)
Pai RK, Cheng YW, Jakubowski MA, Shadrach BL, Plesec TP, Pai RK. Colorectal carcinomas with submucosal invasion (pT1): analysis of histopathological and molecular factors predicting lymph node metastasis. Mod Pathol. 2017;30:113–22. (PMID: 10.1038/modpathol.2016.166)
Berg KB, Schaeffer DF. Tumor budding as a standardized parameter in gastrointestinal carcinomas: more than just the colon. Mod Pathol. 2018;31:862–72. (PMID: 10.1038/s41379-018-0028-4)
Yamaguchi Y, Ishii G, Kojima M, Yoh K, Otsuka H, Otaki Y, et al. Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness. J Thorac Oncol. 2010;5:1361–8. (PMID: 10.1097/JTO.0b013e3181eaf2f3)
Travis WD, Brambilla E, Muller-Hermelink H, Harris CC (eds). Pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: International Agency for Research on Cancer; 2004.
Sumiyoshi S, Yoshizawa A, Sonobe M, Kobayashi M, Sato M, Fujimoto M, et al. Non-terminal respiratory unit type lung adenocarcinoma has three distinct subtypes and is associated with poor prognosis. Lung Cancer. 2014;84:281–8. (PMID: 10.1016/j.lungcan.2014.03.013)
Brierley JD, Gospodarowicz MK, Wittekind C (eds). TNM classification of malignant tumours. 8th ed. Oxford: John Wiley & Sons; 2017.
Sonobe M, Kobayashi M, Ishikawa M, Kikuchi R, Nakayama E, Takahashi T, et al. Impact of KRAS and EGFR gene mutations on recurrence and survival in patients with surgically resected lung adenocarcinomas. Ann Surg Oncol. 2012;19(Suppl 3):S347–54. (PMID: 10.1245/s10434-011-1799-8)
Sonobe M, Manabe T, Wada H, Tanaka F. Lung adenocarcinoma harboring mutations in the ERBB2 kinase domain. J Mol Diagn. 2006;8:351–6. (PMID: 10.2353/jmoldx.2006.050132)
Kobayashi M, Sonobe M, Takahashi T, Yoshizawa A, Ishikawa M, Kikuchi R, et al. Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer. Anticancer Res. 2011;31:4619–23. (PMID: 22199339)
Nakajima N, Yoshizawa A, Kondo K, Rokutan-Kurata M, Hirata M, Furuhata A, et al. Evaluating the effectiveness of RNA in-situ hybridization for detecting lung adenocarcinoma with anaplastic lymphoma kinase rearrangement. Histopathology. 2017;71:143–9. (PMID: 10.1111/his.13198)
Takahashi T, Sonobe M, Kobayashi M, Yoshizawa A, Menju T, Nakayama E, et al. Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene. Ann Surg Oncol. 2010;17:889–97. (PMID: 10.1245/s10434-009-0808-7)
Rokutan-Kurata M, Yoshizawa A, Sumiyoshi S, Sonobe M, Menju T, Momose M, et al. Lung adenocarcinoma with MUC4 expression is associated with smoking status, HER2 protein expression, and poor prognosis: clinicopathologic analysis of 338 cases. Clin Lung Cancer. 2017;18:e273–81. (PMID: 10.1016/j.cllc.2016.11.013)
Moreira AL, Joubert P, Downey RJ, Rekhtman N. Cribriform and fused glands are patterns of high-grade pulmonary adenocarcinoma. Hum Pathol. 2014;45:213–20. (PMID: 10.1016/j.humpath.2013.10.011)
Kuang M, Shen X, Yuan C, Hu H, Zhang Y, Pan Y, et al. Clinical significance of complex glandular patterns in lung adenocarcinoma: clinicopathologic and molecular study in a large series of cases. Am J Clin Pathol. 2018;150:65–73. (PMID: 10.1093/ajcp/aqy032)
Emoto K, Eguchi T, Tan KS, Takahashi Y, Aly RG, Rekhtman N, et al. Expansion of the concept of micropapillary adenocarcinoma to include a newly recognized filigree pattern as well as the classical pattern based on 1468 Stage I lung adenocarcinomas. J Thorac Oncol. 2019;14:1948–61. (PMID: 10.1016/j.jtho.2019.07.008)
Ohe M, Yokose T, Sakuma Y, Miyagi Y, Okamoto N, Osanai S, et al. Stromal micropapillary component as a novel unfavorable prognostic factor of lung adenocarcinoma. Diagn Pathol. 2012;7:3. (PMID: 10.1186/1746-1596-7-3)
Sica G, Yoshizawa A, Sima CS, Azzoli CG, Downey RJ, Rusch VW, et al. A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage I tumors. Am J Surg Pathol. 2010;34:1155–62. (PMID: 10.1097/PAS.0b013e3181e4ee32)
Yoshida A, Tsuta K, Watanabe S, Sekine I, Fukayama M, Tsuda H, et al. Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component. Lung Cancer. 2011;72:309–15. (PMID: 10.1016/j.lungcan.2010.09.013)
Kim H, Jang SJ, Chung DH, Yoo SB, Sun P, Jin Y, et al. A comprehensive comparative analysis of the histomorphological features of ALK-rearranged lung adenocarcinoma based on driver oncogene mutations: frequent expression of epithelial-mesenchymal transition markers than other genotype. PLoS ONE. 2013;8:e76999. (PMID: 10.1371/journal.pone.0076999)
Voena C, Varesio LM, Zhang L, Menotti M, Poggio T, Panizza E, et al. Oncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1. Oncotarget. 2016;7:33316–30. (PMID: 10.18632/oncotarget.8955)
Taira T, Ishii G, Nagai K, Yoh K, Takahashi Y, Matsumura Y, et al. Characterization of the immunophenotype of the tumor budding and its prognostic implications in squamous cell carcinoma of the lung. Lung Cancer. 2012;76:423–30. (PMID: 10.1016/j.lungcan.2011.11.010)
Entry Date(s):
Date Created: 20200422 Date Completed: 20210720 Latest Revision: 20230210
Update Code:
20240105
DOI:
10.1038/s41379-020-0537-9
PMID:
32313186
Czasopismo naukowe
Discohesive growth pattern (Disco-p) is often observed in lung adenocarcinoma (ADC) and mimics tumor budding (TB), stromal invasive-type micropapillary pattern (SMPP), and complex glandular pattern. However, the clinical impact of Disco-p in lung ADC has not been well studied. To investigate the prognostic significance of Disco-p, we analyzed 1062 Japanese patients with resected lung ADC. Disco-p was defined as an invasive growth pattern composed of single tumor cells, or trabeculae or small nests of tumor cells associated with desmoplastic fibrous stroma. We recorded the percentage of Disco-p in 5% increments independent of the major histologic pattern and investigated its correlation with different clinicopathological factors. We also analyzed the overall survival (OS) and disease-free survival (DFS). Disco-p was observed in 203 tumors (19.1%). Disco-p was significantly associated with male sex, smoking, lymph node metastasis, large tumor size, high TNM stage, lymphovascular and pleural invasion, spread through air spaces, and TB (all, p < 0.001). Of the total cases, only eight cases exhibited a dubious pattern between SMPP and Disco-p. Disco-p was also associated with wild-type EGFR (p < 0.001) and ALK fusion (p = 0.008). Patients harboring tumors with Disco-p had significantly worse prognoses (OS and DFS (both, p < 0.001)) compared with those without Disco-p. On multivariate analysis, Disco-p was an independent prognostic factor of worse OS (hazard ratio (HR), 2.572; 95% confidence interval (CI), 1.789-3.680; p < 0.001), and DFS (HR, 3.413; 95% CI, 2.482-4.683; p < 0.001), whereas TB was not an independent unfavorable prognostic factor. Disco-p was an independent unfavorable prognostic factor in patients with resected lung ADC, although a careful evaluation is necessary to distinguish it from similar patterns. We proposed that Disco-p should be recognized as a new invasive pattern and accurately recorded for the better management of patients with lung ADCs.

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