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Tytuł pozycji:

Prevalence, antimicrobial susceptibility patterns, serotypes and risk factors for group B streptococcus rectovaginal isolates among pregnant women at Kenyatta National Hospital, Kenya; a cross-sectional study.

Tytuł:
Prevalence, antimicrobial susceptibility patterns, serotypes and risk factors for group B streptococcus rectovaginal isolates among pregnant women at Kenyatta National Hospital, Kenya; a cross-sectional study.
Autorzy:
Jisuvei SC; Institute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya. .; Research and Programs Department, Kenyatta National Hospital, Nairobi, Kenya. .
Osoti A; Department of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya.
Njeri MA; Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
Źródło:
BMC infectious diseases [BMC Infect Dis] 2020 Apr 22; Vol. 20 (1), pp. 302. Date of Electronic Publication: 2020 Apr 22.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: London : BioMed Central, [2001-
MeSH Terms:
Microbial Sensitivity Tests*
Pregnancy Complications, Infectious/*epidemiology
Rectum/*microbiology
Streptococcal Infections/*epidemiology
Streptococcus agalactiae/*classification
Streptococcus agalactiae/*isolation & purification
Vagina/*microbiology
Adult ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cross-Sectional Studies ; Female ; Humans ; Kenya/epidemiology ; Pregnancy ; Pregnancy Complications, Infectious/microbiology ; Prevalence ; Risk Factors ; Serogroup ; Serotyping ; Streptococcal Infections/drug therapy ; Streptococcal Infections/microbiology ; Streptococcus agalactiae/drug effects
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Grant Information:
not given National Research Fund of Kenya
Contributed Indexing:
Keywords: Antimicrobial susceptibility; Group B Streptococcus; Kenya; Pregnant women; Serotypes
Substance Nomenclature:
0 (Anti-Bacterial Agents)
Entry Date(s):
Date Created: 20200424 Date Completed: 20200525 Latest Revision: 20200525
Update Code:
20240105
PubMed Central ID:
PMC7178604
DOI:
10.1186/s12879-020-05035-1
PMID:
32321444
Czasopismo naukowe
Background: Estimates of Group B Streptococcus (GBS) disease burden, antimicrobial susceptibility, and serotypes in pregnant women are limited for many resource-limited countries including Kenya. These data are required to inform recommendations for prophylaxis and treatment of infections due to GBS.
Methods: We evaluated the prevalence, antimicrobial susceptibility patterns, serotypes, and risk factors associated with rectovaginal GBS colonization among pregnant women receiving antenatal care at Kenyatta National Hospital (KNH) between August and November 2017. Consenting pregnant women between 12 and 40 weeks of gestation were enrolled. Interview-administered questionnaires were used to assess risk factors associated with GBS colonization. An anorectal swab and a lower vaginal swab were collected and cultured on Granada agar for GBS isolation. Positive colonies were tested for antimicrobial susceptibility to penicillin G, ampicillin, vancomycin, and clindamycin using the disk diffusion method. Serotyping was performed by latex agglutination. Logistic regression was used to identify factors associated with GBS colonization.
Results: A total of 292 women were enrolled. Median age was 30 years (Interquartile range {IQR} 26-35) and a median gestational age of 35 weeks (IQR 30-37). Overall GBS was identified in 60/292 (20.5%) of participants. Among the positive isolates, resistance was detected for penicillin G in 42/58 (72.4%) isolates, ampicillin in 32/58 (55.2%) isolates, clindamycin in 14/46 (30.4%) isolates, and vancomycin in 14/58 (24.1%) isolates. All ten GBS serotypes were isolated, and 37/53 (69.8%) of GBS positive participants were colonized by more than one serotype. None of the risk factors was associated with GBS colonization.
Conclusion: The prevalence of GBS colonization was high among antenatal women at KNH. In addition, a high proportion of GBS isolates were resistant to commonly prescribed intrapartum antibiotics. Hence, other measures like GBS vaccination is a potentially useful approaches to GBS prevention and control in this population. Screening of pregnant mothers for GBS colonization should be introduced and antimicrobial susceptibility test performed on GBS positive samples to guide antibiotic prophylaxis.
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