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Tytuł:
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IL-12B Polymorphisms Are Associated with the Presence of Premature Coronary Artery Disease and with Cardiovascular Risk Factors: The Genetics of Atherosclerotic Disease Mexican Study.
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Autorzy:
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Vázquez-Vázquez C; Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Posadas-Sánchez R; Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Fragoso JM; Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Ramírez-Bello J; Research Unit on Endocrine and Metabolic Diseases, Hospital Juárez de México, Mexico City, Mexico.
Sánchez-Guerra M; Department of Developmental Neurobiology, Instituto Nacional de Perinatología, Mexico City, Mexico.
Osorio-Yañez C; Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de Mexico, Mexico City, Mexico.
Vargas-Alarcón G; Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
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Źródło:
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DNA and cell biology [DNA Cell Biol] 2020 Jul; Vol. 39 (7), pp. 1347-1355. Date of Electronic Publication: 2020 Apr 29.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Larchmont, NY : Mary Ann Liebert
Original Publication: [New York, NY] : Mary Ann Liebert, [c1990-
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MeSH Terms:
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Polymorphism, Single Nucleotide*
Atherosclerosis/*genetics
Coronary Artery Disease/*genetics
Interleukin-12 Subunit p40/*genetics
Coronary Artery Disease/epidemiology ; Female ; Genetic Predisposition to Disease/genetics ; Haplotypes ; Humans ; Male ; Mexico/epidemiology ; Middle Aged ; Risk Factors
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Contributed Indexing:
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Keywords: beta p40 subunit; cardiovascular risk factors; coronary artery disease; polymorphisms
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Substance Nomenclature:
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0 (IL12B protein, human)
0 (Interleukin-12 Subunit p40)
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Entry Date(s):
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Date Created: 20200501 Date Completed: 20200720 Latest Revision: 20200720
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Update Code:
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20240105
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DOI:
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10.1089/dna.2020.5464
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PMID:
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32352837
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The aim of this study was to evaluate the association of the IL-12B polymorphisms with the presence of premature coronary artery disease (pCAD) and with cardiovascular risk factors. The study included 2163 individuals (1133 patients with pCAD and 1030 healthy controls). Seven IL-12B polymorphisms (rs1363670, rs3212220, rs3212227, rs6887695, rs1433048, rs2853694, and rs1368439) were determined by TaqMan assays. The associations were evaluated by logistic regression using inheritance models adjusted for confounding variables. The rs1363670 was associated with a low risk of pCAD (odds ratio [OR] 0.718, p dominant = 0.034; OR 0.701, p heterozygote = 0.024; OR 0.702, p codominant1 = 0.025). The association of the polymorphisms with cardiovascular risk factors was evaluated independently in each group. In controls, the rs3212227, rs3212220, and rs6887695 polymorphisms were associated with subcutaneous abdominal fat > p75, whereas the rs6887695 was associated with a high risk of central obesity. In pCAD patients, the rs2853694 was associated with a low risk of insulin resistance; and association of rs3212227 and rs3212220 with a low risk of metabolic syndrome was found, and the rs6887695 polymorphism was nominally associated with a high risk of hyperuricemia. In conclusion, the IL-12B rs1363670 polymorphism was associated with a low risk of pCAD, and in both pCAD patients and healthy controls, some IL-12B polymorphisms were associated with cardiovascular risk factors.
