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Tytuł pozycji:

Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm.

Tytuł :
Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm.
Autorzy :
Quinn TA; Department of Physiology and Biophysics and School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada; Institute for Experimental Cardiovascular Medicine, University Heart Centre Freiburg/Bad Krozingen, Medical Faculty of the University of Freiburg, Freiburg, Germany; and CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
Kohl P; Department of Physiology and Biophysics and School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada; Institute for Experimental Cardiovascular Medicine, University Heart Centre Freiburg/Bad Krozingen, Medical Faculty of the University of Freiburg, Freiburg, Germany; and CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
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Źródło :
Physiological reviews [Physiol Rev] 2021 Jan 01; Vol. 101 (1), pp. 37-92. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Bethesda, MD : American Physiological Society
Original Publication: Washington [etc.] American Physiological Society.
Grant Information :
MOP 342562 Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de recherche en santé du Canada); RGPIN-2016-04879 Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada); National New Investigator Award Heart and Stroke Foundation of Canada (Fondation des maladies du cœur du Canada); 323099 EC | European Research Council (ERC)
Contributed Indexing :
Keywords: arrhythmias; autoregulation; cardiac; mechano-electric coupling; stretch
Entry Date(s) :
Date Created: 20200509 Latest Revision: 20201012
Update Code :
20201218
DOI :
10.1152/physrev.00036.2019
PMID :
32380895
Czasopismo naukowe
The heart is vital for biological function in almost all chordates, including humans. It beats continually throughout our life, supplying the body with oxygen and nutrients while removing waste products. If it stops, so does life. The heartbeat involves precise coordination of the activity of billions of individual cells, as well as their swift and well-coordinated adaption to changes in physiological demand. Much of the vital control of cardiac function occurs at the level of individual cardiac muscle cells, including acute beat-by-beat feedback from the local mechanical environment to electrical activity (as opposed to longer term changes in gene expression and functional or structural remodeling). This process is known as mechano-electric coupling (MEC). In the current review, we present evidence for, and implications of, MEC in health and disease in human; summarize our understanding of MEC effects gained from whole animal, organ, tissue, and cell studies; identify potential molecular mediators of MEC responses; and demonstrate the power of computational modeling in developing a more comprehensive understanding of ‟what makes the heart tick.ˮ.

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