Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications.

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Tytuł:: Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications.
Autorzy:: Miller B; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Kim SJ; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Kumagai H; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Mehta HH; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Xiang W; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Liu J; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Yen K; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Cohen P; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. Electronic address: .
Źródło:: Experimental cell research [Exp Cell Res] 2020 Aug 15; Vol. 393 (2), pp. 112056. Date of Electronic Publication: 2020 May 06.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Review
Język:: English
Imprint Name(s):: Publication: Orlando Fl : Academic Press
Original Publication: New York, Academic Press.
MeSH Terms:: DNA, Mitochondrial/*genetics
Mitochondria/*metabolism
Open Reading Frames/*genetics
Peptides/*genetics
Cardiovascular Diseases/genetics ; Genomics/methods ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mitochondria/genetics ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Peptides/metabolism
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Grant Information:: R01 AG069698 United States AG NIA NIH HHS; R56 AG062693 United States AG NIA NIH HHS; RF1 AG061834 United States AG NIA NIH HHS; R01 EY027363 United States EY NEI NIH HHS; U54 CA233465 United States CA NCI NIH HHS; T32 AG000037 United States AG NIA NIH HHS; R01 AG068405 United States AG NIA NIH HHS; P01 AG034906 United States AG NIA NIH HHS
Contributed Indexing:: Keywords: Microproteins; Mitochondrial-derived peptides; Small open reading frames
Substance Nomenclature:: 0 (DNA, Mitochondrial)
0 (Intracellular Signaling Peptides and Proteins)
0 (Mitochondrial Proteins)
0 (Peptides)
0 (humanin)
Entry Date(s):: Date Created: 20200511 Date Completed: 20210201 Latest Revision: 20240330
Update Code:: 20240330
PubMed Central ID:: PMC7778388
DOI:: 10.1016/j.yexcr.2020.112056
PMID:: 32387288
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Mitochondrial-derived peptides (MDPs) are a novel class of bioactive microproteins that modify cell metabolism. The the eight MDPs that been characterized (e.g., humanin, MOTS-c, SHLPs1-6) attenuate disease pathology including Alzheimer's disease, prostate cancer, macular degeneration, cardiovascular disease, and diabetes. The association between disease and human genetic variation in MDPs is underexplored, although two polymorphisms in humanin and MOTS-c associate with cognitive decline and diabetes, respectively, suggesting a precise role for MDPs in disease-modification. There could be hundreds of additional MDPs that have yet to be discovered. Altogether, MDPs could explain unanswered biological and metabolic questions and are part of a growing field of novel microproteins encoded by small open reading frames. In this review, the current state of MDPs are summarized with an emphasis on biological and therapeutic implications.
(Copyright © 2020. Published by Elsevier Inc.)

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