Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell.

Tytuł:: Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell.
Autorzy:: Wang QY; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Xu YS; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Zhang NX; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Dong ZP; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Zhao BN; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Liu LC; Department of Rheumatology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Lu T; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Wang Y; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Źródło:: Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 681-690.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2015->: Abingdon, Oxford : Taylor & Francis
Original Publication: Orlando, FL : Academic Press, c1993-
MeSH Terms:: Antibiotics, Antineoplastic/*administration & dosage
Biocompatible Materials/*chemistry
Boronic Acids/*chemistry
Doxorubicin/*administration & dosage
Drug Carriers/*chemistry
Polyethylene Glycols/*chemistry
Reactive Oxygen Species/*metabolism
A549 Cells ; Animals ; Anions ; Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/pharmacokinetics ; Antibiotics, Antineoplastic/pharmacology ; Cell Survival/drug effects ; Doxorubicin/chemistry ; Doxorubicin/pharmacokinetics ; Doxorubicin/pharmacology ; Drug Liberation ; HeLa Cells ; Humans ; MCF-7 Cells ; Mice ; Micelles ; Molecular Structure ; Xenograft Model Antitumor Assays
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Contributed Indexing:: Keywords: Anionic micelles; ROS-Stimuli response; drug delivery system
Substance Nomenclature:: 0 (Anions)
0 (Antibiotics, Antineoplastic)
0 (Biocompatible Materials)
0 (Boronic Acids)
0 (Drug Carriers)
0 (Micelles)
0 (Reactive Oxygen Species)
0 (polyethylene glycol-block-polyaspartic acid)
3WJQ0SDW1A (Polyethylene Glycols)
80168379AG (Doxorubicin)
L12H7B02G5 (benzeneboronic acid)
Entry Date(s):: Date Created: 20200513 Date Completed: 20210203 Latest Revision: 20240330
Update Code:: 20240330
PubMed Central ID:: PMC7269054
DOI:: 10.1080/10717544.2020.1748761
PMID:: 32393138
: Czasopismo naukowe

Pełny tekst

Smart polymers as ideal drug nanocarriers have attracted much attention due to the effective drug delivery, internalization and release once triggered by intracellular stimuli, as well as reduced cytotoxicity. We here reported the anionic micelle consisting of copolymer (PEG-b-PAsp) and a PBE (Phenylboronic Ester) group grafted, which can achieve fast response to intracellular ROS and enhanced anti-tumor activity. With this, PEG-b-PAsp-g-PBE/DOX system showed better tumor growth inhibition when studied on HeLa cell lines with high level of intracellular ROS and its subcutaneous tumor models. Additionally, the administration of PEG-b-PAsp-g-PBE/DOX did cause significantly lower systemic toxicity in comparison with free DOX. Hence, PEG-b-PAsp-g-PBE could be a highly efficient and safe nanocarrier to improve the efficacy of chemotherapeutic.

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