Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Kidney and vascular function in adult patients with hereditary fructose intolerance.

Tytuł :
Kidney and vascular function in adult patients with hereditary fructose intolerance.
Autorzy :
Simons N; Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.; Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.
Debray FG; Department of Medical Genetics, Metabolic Unit, University Hospital Liège, Liège, Belgium.
Schaper NC; Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; CAPHRI School for Public Health and Primary Care, Maastricht, The Netherlands.
Feskens EJM; Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Hollak CEM; Division of Endocrinology and Metabolism, Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Bons JAP; Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.
Bierau J; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
Houben AJHM; Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Schalkwijk CG; Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.
Stehouwer CDA; Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.; Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Cassiman D; Department of Gastroenterology-Hepatology and Metabolic Center, University Hospital Leuven, Leuven, Belgium.
Brouwers MCGJ; Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.; Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.
Pokaż więcej
Źródło :
Molecular genetics and metabolism reports [Mol Genet Metab Rep] 2020 May 11; Vol. 23, pp. 100600. Date of Electronic Publication: 2020 May 11 (Print Publication: 2020).
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: [New York, NY] : Elsevier Inc., [2014]-
References :
Mol Cell Proteomics. 2014 Feb;13(2):397-406. (PMID: 24309898)
Transl Res. 2011 Mar;157(3):111-6. (PMID: 21316027)
Clin Chim Acta. 2009 Sep;407(1-2):36-42. (PMID: 19559691)
Kidney Int. 2011 Feb;79(4):471-7. (PMID: 20980977)
N Engl J Med. 1983 Sep 29;309(13):764-70. (PMID: 6888454)
Lasers Med Sci. 2009 Mar;24(2):269-83. (PMID: 18236103)
Helv Paediatr Acta. 1978 Dec;33(6):465-87. (PMID: 738900)
JAMA. 2004 Apr 28;291(16):1978-86. (PMID: 15113816)
JAMA. 2013 Nov 27;310(20):2191-4. (PMID: 24141714)
J Lab Clin Med. 1976 Mar;87(3):411-34. (PMID: 1249473)
Nephrol Dial Transplant. 2012 May;27(5):1821-5. (PMID: 22140135)
Lancet. 1956 Aug 18;271(6938):340. (PMID: 13358219)
Cardiovasc Res. 2011 Dec 1;92(3):494-503. (PMID: 21890532)
Hum Mol Genet. 2009 Nov 1;18(21):4081-8. (PMID: 19643913)
J Clin Invest. 2018 Jun 1;128(6):2226-2238. (PMID: 29533924)
Eur J Clin Nutr. 2015 Apr;69(4):475-81. (PMID: 25514900)
PLoS One. 2012;7(7):e41495. (PMID: 22911800)
Clin Nutr. 2020 Feb;39(2):455-459. (PMID: 30833214)
Nutrients. 2019 Oct 07;11(10):. (PMID: 31591370)
J Clin Endocrinol Metab. 2019 Nov 1;104(11):5056-5064. (PMID: 30901028)
Circulation. 1997 Dec 16;96(12):4219-25. (PMID: 9416885)
PLoS Genet. 2011 Mar;7(3):e1001324. (PMID: 21423719)
Scand J Clin Lab Invest. 1999 Dec;59(8):587-92. (PMID: 10691049)
Lancet. 1990 Feb 10;335(8685):306-9. (PMID: 1967768)
Am J Med. 1978 Sep;65(3):416-23. (PMID: 213970)
Circulation. 2016 Nov 1;134(18):1339-1352. (PMID: 27678264)
Helv Paediatr Acta. 1981;36(6):599-600. (PMID: 7333867)
Hypertension. 1980 Sep-Oct;2(5):695-9. (PMID: 7419270)
J Appl Physiol (1985). 2014 Aug 1;117(3):277-83. (PMID: 24903917)
PLoS One. 2018 Oct 23;13(10):e0206174. (PMID: 30352097)
Hypertension. 2018 Jun;71(6):e13-e115. (PMID: 29133356)
Nephrol Dial Transplant. 2016 Aug;31(8):1295-301. (PMID: 26610595)
Ann Clin Biochem. 1998 Mar;35 ( Pt 2):201-6. (PMID: 9547891)
Hum Mutat. 2010 Dec;31(12):1294-303. (PMID: 20848650)
PLoS One. 2014 May 22;9(5):e97656. (PMID: 24852037)
J Am Coll Cardiol. 2004 Dec 7;44(11):2137-41. (PMID: 15582310)
Diabetologia. 2008 Apr;51(4):527-39. (PMID: 18239908)
Diabetes. 2018 Sep;67(9):1729-1741. (PMID: 30135134)
Ann Intern Med. 2009 May 5;150(9):604-12. (PMID: 19414839)
N Engl J Med. 2001 Jan 4;344(1):3-10. (PMID: 11136953)
Clin Sci (Lond). 2008 Jan;114(2):109-18. (PMID: 18062776)
Nat Rev Nephrol. 2012 Feb 21;8(5):293-300. (PMID: 22349487)
Am J Med. 1968 Dec;45(6):826-38. (PMID: 4235454)
Am J Med. 1963 Feb;34:151-67. (PMID: 13959929)
Kidney Int. 2004 Nov;66(5):1994-2003. (PMID: 15496171)
Clin Sci (Lond). 2017 Feb 1;131(4):309-325. (PMID: 28007970)
Am J Dis Child. 1978 Jun;132(6):605-8. (PMID: 655145)
Clin J Am Soc Nephrol. 2016 Dec 7;11(12):2186-2194. (PMID: 27683625)
J Med Genet. 1998 May;35(5):353-65. (PMID: 9610797)
Eur Heart J. 2006 Nov;27(21):2588-605. (PMID: 17000623)
Contributed Indexing :
Keywords: 95% confidence interval, (95% CI); Blood; CKD-EPI equation based on creatinine and cystatin c combined, (eGFRcr-cys); CKD-EPI equation based on cystatin c, (eGFRcys); CKD-EPI equation based on serum creatinine, (eGFRcr); Case-control study; Fanconi syndrome; Hereditary fructose intolerance; Kidney; Vessels; alanine, (Ala); aldolase B, (ALDOB); arginine, (Arg); asparagine, (Asn); carotid-femoral pulse wave velocity, (cf-PWV); chronic kidney disease epidemiology collaboration, (CKD-EPI); citrulline, (Cit); cysteine, (Cys); difference, (Δ); estimated glomerular filtration rate, (eGFR); glucokinase regulatory protein, (GKRP); glutamic acid, (Glu); glutamine, (Gln); glycine, (Gly); hereditary fructose intolerance, (HFI); histidine, (His); intrahepatic triglyceride, (IHTG); isoleucine, (Ile); laser doppler flowmetry, (LDF); leucine, (Leu); lysine, (Lys); methionine, (Met); ornithine, (Orn); perfusion units, (PU); phenylalanine, (Phe); proline, (Pro); ratio of tubular maximum reabsorption of phosphate to GFR, (TmP/GFR); reactive hyperemia index, (RHI); reactive hyperemia peripheral arterial tonometry, (RH-PAT); serine, (Ser); soluble E-selectin, (sE-selectin); statistical package of social sciences, (SPSS); taurine, (Tau); threonine, (Thr); tryptophan, (Try); tubular reabsorption of phosphate, (TRP); tyrosine, (Tyr); valine, (Val); von willebrand factor, (vWF)
Entry Date(s) :
Date Created: 20200520 Latest Revision: 20200928
Update Code :
20210210
PubMed Central ID :
PMC7225396
DOI :
10.1016/j.ymgmr.2020.100600
PMID :
32426234
Czasopismo naukowe
Objective : Previous studies have shown that patients with hereditary fructose intolerance (HFI) are characterized by a greater intrahepatic triglyceride content, despite a fructose-restricted diet. The present study aimed to examine the long-term consequences of HFI on other aldolase-B-expressing organs, i.e. the kidney and vascular endothelium. Methods : Fifteen adult HFI patients were compared to healthy control individuals matched for age, sex and body mass index. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (cf-PWV) and endothelial function by peripheral arterial tonometry, skin laser doppler flowmetry and the endothelial function biomarkers soluble E -selectin [sE-selectin] and von Willebrand factor. Serum creatinine and cystatin C were measured to estimate the glomerular filtration rate (eGFR). Urinary glucose and amino acid excretion and the ratio of tubular maximum reabsorption of phosphate to GFR (TmP/GFR) were determined as measures of proximal tubular function. Results : Median systolic blood pressure was significantly higher in HFI patients (127 versus 122 mmHg, p  = .045). Pulse pressure and cf-PWV did not differ between the groups ( p  = .37 and p  = .49, respectively). Of all endothelial function markers, only sE-selectin was significantly higher in HFI patients ( p  = .004). eGFR was significantly higher in HFI patients than healthy controls (119 versus 104 ml/min/1.73m 2 , p  = .001, respectively). All measurements of proximal tubular function did not differ significantly between the groups. Conclusions : Adult HFI patients treated with a fructose-restricted diet are characterized by a higher sE-selectin level and slightly higher systolic blood pressure, which in time could contribute to a greater cardiovascular risk. The exact cause and, hence, clinical consequences of the higher eGFR in HFI patients, deserves further study.
(© 2020 The Authors.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies