Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions.

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Abstrakt

Tytuł:: Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions.
Autorzy:: Iovino F; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-17165 Stockholm, Sweden. .
Merkl P
Spyrogianni A
Henriques-Normark B
Sotiriou GA
Źródło:: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jun 25; Vol. 56 (51), pp. 6989-6992.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Cambridge : Royal Society of Chemistry
MeSH Terms:: Host-Pathogen Interactions*
Optical Imaging*
Fluorescent Dyes/*chemistry
Nanoparticles/*chemistry
Silicon Dioxide/*chemistry
Streptococcus pneumoniae/*isolation & purification
A549 Cells ; Host Microbial Interactions ; Humans ; Microscopy, Fluorescence ; Particle Size ; Surface Properties
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Substance Nomenclature:: 0 (Fluorescent Dyes)
7631-86-9 (Silicon Dioxide)
Entry Date(s):: Date Created: 20200523 Date Completed: 20210201 Latest Revision: 20240329
Update Code:: 20240329
PubMed Central ID:: PMC7116283
DOI:: 10.1039/d0cc00329h
PMID:: 32441283
: Czasopismo naukowe

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Fluorescence in vitro bioimaging suffers from photobleaching of organic dyes, thus, functional probes with superior photostability are urgently needed. Here, we address this challenge by developing novel silica-coated nanophosphors that may serve as superior luminescent nanoprobes compatible with conventional fluorescence microscopes. We specifically explore their suitability for dynamic in vitro bioimaging of interactions between bacterial pathogens and host cells, and further demonstrate the facile surface functionalization of the amorphous silica layer with antibodies for selective cell targeting.

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