Oxytocin receptor gene and parental bonding modulate prefrontal responses to cries: a NIRS Study.

Tytuł:: Oxytocin receptor gene and parental bonding modulate prefrontal responses to cries: a NIRS Study.
Autorzy:: Cataldo I; Affiliative Behavior and Physiology Lab, Department of Psychology and Cognitive Science, University of Trento, Rovereto, TN, Italy.; Mobile and Social Computing Lab, Bruno Kessler Foundation, Trento, Italy.
Neoh MJ; Social and Affective Neuroscience Lab, Psychology Program, School of Social Sciences, Nanyang Technological University, Singapore, Singapore.
Chew WF; Social and Affective Neuroscience Lab, Psychology Program, School of Social Sciences, Nanyang Technological University, Singapore, Singapore.
Foo JN; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Lepri B; Mobile and Social Computing Lab, Bruno Kessler Foundation, Trento, Italy.
Esposito G; Affiliative Behavior and Physiology Lab, Department of Psychology and Cognitive Science, University of Trento, Rovereto, TN, Italy. .; Social and Affective Neuroscience Lab, Psychology Program, School of Social Sciences, Nanyang Technological University, Singapore, Singapore. .; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. .
Źródło:: Scientific reports [Sci Rep] 2020 May 22; Vol. 10 (1), pp. 8588. Date of Electronic Publication: 2020 May 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Gene-Environment Interaction*
Polymorphism, Genetic*
Neurons/*physiology
Parenting/*psychology
Parents/*psychology
Prefrontal Cortex/*physiopathology
Receptors, Oxytocin/*genetics
Adult ; Child ; Emotions ; Female ; Humans ; Male ; Object Attachment ; Parent-Child Relations ; Social Environment ; Spectroscopy, Near-Infrared ; Stress, Psychological ; Young Adult
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Substance Nomenclature:: 0 (Receptors, Oxytocin)
Entry Date(s):: Date Created: 20200524 Date Completed: 20201201 Latest Revision: 20210522
Update Code:: 20240105
PubMed Central ID:: PMC7244477
DOI:: 10.1038/s41598-020-65582-0
PMID:: 32444796
: Czasopismo naukowe

Pełny tekst

The ability to interpret and regulate emotions relies on experiences of emotional socialization, obtained firstly through the interaction with the parents, and on genetic features that affect how individuals take on social situations. Evidence from the genetic field states that specific allelic variations of the oxytocin receptor gene polymorphisms regulate physiological modulation of human behavior, especially concerning responses to social cues and affiliative behaviors. Starting from this gene-by-environment interaction frame, we assessed 102 young adults for OXTr rs53576 and rs2254298, recalled parental bonding (using the Parental Bonding Instrument), and recorded participants' neural responses to social stressors using Near InfraRed Spectroscopy (NIRS). The results highlight that higher genetic susceptibility (G/G homozygous) to familiar context and positive early life interactions modulate more optimal neural responses to general social cues, in terms of promptness to action. With regards to the dimensions of parental bonding, we found lateralized effects, with greater activation in the right prefrontal cortex for Care subscales, and on the left side of the prefrontal cortex for Overprotection. Results provide evidence to understand the neurological mechanisms behind the negative impact of poor parenting practices on the child.

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