Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Is Merkel Cell Carcinoma of Lymph Node Actually Metastatic Cutaneous Merkel Cell Carcinoma?

Tytuł :
Is Merkel Cell Carcinoma of Lymph Node Actually Metastatic Cutaneous Merkel Cell Carcinoma?
Autorzy :
Lawrence LEB; Department of Pathology, Stanford University School of Medicine, Stanford, CA.
Saleem A; Department of Pathology, Stanford University School of Medicine, Stanford, CA.
Sahoo MK; Department of Pathology, Stanford University School of Medicine, Stanford, CA.
Tan SK; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA.
Pinsky BA; Department of Pathology, Stanford University School of Medicine, Stanford, CA.; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA.
Natkunam Y; Department of Pathology, Stanford University School of Medicine, Stanford, CA.
Kunder CA; Department of Pathology, Stanford University School of Medicine, Stanford, CA.
Stehr H; Department of Pathology, Stanford University School of Medicine, Stanford, CA.
Zehnder JL; Department of Pathology, Stanford University School of Medicine, Stanford, CA.
Pokaż więcej
Źródło :
American journal of clinical pathology [Am J Clin Pathol] 2020 Aug 05; Vol. 154 (3), pp. 369-380.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: 2016- : Oxford : Oxford University Press
Original Publication: Philadelphia [etc.] Lippincott [etc.]
MeSH Terms :
Carcinoma, Merkel Cell/*pathology
Carcinoma, Neuroendocrine/*pathology
Lymph Nodes/*pathology
Lymphatic Metastasis/*pathology
Skin Neoplasms/*pathology
Carcinoma, Merkel Cell/virology ; Carcinoma, Neuroendocrine/virology ; Humans ; Lymph Nodes/virology ; Merkel cell polyomavirus ; Skin Neoplasms/virology ; Tumor Virus Infections/pathology ; Tumor Virus Infections/virology
Contributed Indexing :
Keywords: Lymph node*; Merkel cell carcinoma*; Merkel cell polyomavirus*; Mutational signatures*; UV mutational signature*
Entry Date(s) :
Date Created: 20200524 Date Completed: 20201019 Latest Revision: 20201019
Update Code :
20201023
DOI :
10.1093/ajcp/aqaa051
PMID :
32445471
Czasopismo naukowe
Objectives: The possibility of a so-called primary lymph node neuroendocrine carcinoma has been described in the literature. Here we evaluate cases fitting such a diagnosis and find that the cases demonstrate a convincing and pervasive pattern consistent with metastatic Merkel cell carcinoma.
Methods: Six cases of primary lymph node Merkel cell carcinoma and one case of metastatic neuroendocrine carcinoma at a bony site, all with unknown primary, were sequenced using a combination of whole-exome and targeted panel methods. Sequencing results were analyzed for the presence of an ultraviolet (UV) mutational signature or off-target detection of Merkel cell polyomavirus (MCPyV).
Results: Four of six primary lymph node cases were positive for a UV mutational signature, with the remaining two cases positive for off-target alignment of MCPyV. One case of neuroendocrine carcinoma occurring at a bony site was also positive for a UV mutational signature.
Conclusions: We find no evidence to corroborate the existence of so-called primary Merkel cell carcinoma of lymph node.
(© American Society for Clinical Pathology, 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies