Arousal Modulates Retinal Output.

Tytuł:: Arousal Modulates Retinal Output.
Autorzy:: Schröder S; UCL Institute of Ophthalmology, University College London, London WC1E 6BT, UK. Electronic address: .
Steinmetz NA; UCL Queen Square Institute of Neurology, University College London, London WC1E 6BT, UK.
Krumin M; UCL Institute of Ophthalmology, University College London, London WC1E 6BT, UK.
Pachitariu M; HHMI Janelia Research Campus, Ashburn, VA 20147, USA.
Rizzi M; UCL Institute of Ophthalmology, University College London, London WC1E 6BT, UK.
Lagnado L; School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.
Harris KD; UCL Queen Square Institute of Neurology, University College London, London WC1E 6BT, UK.
Carandini M; UCL Institute of Ophthalmology, University College London, London WC1E 6BT, UK.
Źródło:: Neuron [Neuron] 2020 Aug 05; Vol. 107 (3), pp. 487-495.e9. Date of Electronic Publication: 2020 May 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [Cambridge, Mass. : Cell Press, c1988-
MeSH Terms:: Arousal/*physiology
Axons/*physiology
Neurons/*physiology
Orientation, Spatial/*physiology
Retinal Ganglion Cells/*physiology
Superior Colliculi/*physiology
Animals ; Axons/metabolism ; Locomotion ; Mice ; Neurons/cytology ; Neurons/metabolism ; Optic Tract ; Presynaptic Terminals/metabolism ; Retinal Ganglion Cells/cytology ; Retinal Ganglion Cells/metabolism ; Superior Colliculi/diagnostic imaging ; Superior Colliculi/metabolism ; Visual Pathways/physiology ; Wakefulness
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Grant Information:: 102264 United Kingdom WT_ Wellcome Trust; BB/P003273/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; 205093 United Kingdom WT_ Wellcome Trust; United States HHMI Howard Hughes Medical Institute; 205093/Z/16/Z United Kingdom WT_ Wellcome Trust; United Kingdom WT_ Wellcome Trust; 102905 United Kingdom WT_ Wellcome Trust
Contributed Indexing:: Keywords: arousal; locomotion; retina; superior colliculus; vision
Entry Date(s):: Date Created: 20200524 Date Completed: 20201019 Latest Revision: 20230315
Update Code:: 20240105
PubMed Central ID:: PMC7427318
DOI:: 10.1016/j.neuron.2020.04.026
PMID:: 32445624
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At various stages of the visual system, visual responses are modulated by arousal. Here, we find that in mice this modulation operates as early as in the first synapse from the retina and even in retinal axons. To measure retinal activity in the awake, intact brain, we imaged the synaptic boutons of retinal axons in the superior colliculus. Their activity depended not only on vision but also on running speed and pupil size, regardless of retinal illumination. Arousal typically reduced their visual responses and selectivity for direction and orientation. Recordings from retinal axons in the optic tract revealed that arousal modulates the firing of some retinal ganglion cells. Arousal had similar effects postsynaptically in colliculus neurons, independent of activity in the other main source of visual inputs to the colliculus, the primary visual cortex. These results indicate that arousal modulates activity at every stage of the mouse visual system.
Competing Interests: Declaration of Interests The authors declare no competing interests.
(Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)

Comment in: Curr Biol. 2020 Oct 19;30(20):R1263-R1266. (PMID: 33080197)

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