Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain.

Szczegóły
Abstrakt

Tytuł:: Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain.
Autorzy:: Sun Z; Department of Molecular and Cellular Biology; Baylor College of Medicine, Houston, Texas.; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism; Baylor College of Medicine, Houston, Texas.
Xu Y; Department of Molecular and Cellular Biology; Baylor College of Medicine, Houston, Texas.; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics; Baylor College of Medicine, Houston, Texas.
Źródło:: Endocrinology [Endocrinology] 2020 Aug 01; Vol. 161 (8).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
Język:: English
Imprint Name(s):: Publication: 2017- : New York : Oxford University Press
Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions,
MeSH Terms:: Brain/*metabolism
Co-Repressor Proteins/*physiology
Nuclear Receptor Coactivators/*physiology
Animals ; Behavior/physiology ; Brain/physiology ; Co-Repressor Proteins/metabolism ; Humans ; Neurosecretory Systems/physiology ; Nuclear Receptor Coactivators/metabolism ; Transcriptional Activation
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Grant Information:: P01 DK113954 United States DK NIDDK NIH HHS; R01 DK115761 United States DK NIDDK NIH HHS; P50 CA126752 United States CA NCI NIH HHS; R01 DK111436 United States DK NIDDK NIH HHS; R01 ES027544 United States ES NIEHS NIH HHS; R21 CA215591 United States CA NCI NIH HHS; P30 ES030285 United States ES NIEHS NIH HHS; P30 CA125123 United States CA NCI NIH HHS; P30 DK056338 United States DK NIDDK NIH HHS; R01 DK117281 United States DK NIDDK NIH HHS
Contributed Indexing:: Keywords: behavior; brain; neuroendocrine; nuclear receptor corepressor (NCOR); steroid receptor coactivator (SRC)
Substance Nomenclature:: 0 (Co-Repressor Proteins)
0 (Nuclear Receptor Coactivators)
Entry Date(s):: Date Created: 20200526 Date Completed: 20210104 Latest Revision: 20210104
Update Code:: 20240105
PubMed Central ID:: PMC7351129
DOI:: 10.1210/endocr/bqaa083
PMID:: 32449767
: Czasopismo naukowe

Nuclear receptor coactivators (NCOAs) and corepressors (NCORs) bind to nuclear hormone receptors in a ligand-dependent manner and mediate the transcriptional activation or repression of the downstream target genes in response to hormones, metabolites, xenobiotics, and drugs. NCOAs and NCORs are widely expressed in the mammalian brain. Studies using genetic animal models started to reveal pivotal roles of NCOAs/NCORs in the brain in regulating hormonal signaling, sexual behaviors, consummatory behaviors, exploratory and locomotor behaviors, moods, learning, and memory. Genetic variants of NCOAs or NCORs have begun to emerge from human patients with obesity, hormonal disruption, intellectual disability, or autism spectrum disorders. Here we review recent studies that shed light on the function of NCOAs and NCORs in the central nervous system.
(© Endocrine Society 2020.)

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