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Tytuł:
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Predictive power of novel and established obesity indices for outcome in PAD during a five-year follow-up.
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Autorzy:
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Zierfuss B; Division of Angiology, Department of Internal Medicine 2, Medical University of Vienna, Austria. Electronic address: .
Höbaus C; Division of Angiology, Department of Internal Medicine 2, Medical University of Vienna, Austria.
Herz CT; Division of Endocrinology and Metabolism, Department of Internal Medicine 3, Medical University of Vienna, Austria.
Pesau G; Division of Angiology, Department of Internal Medicine 2, Medical University of Vienna, Austria.
Koppensteiner R; Division of Angiology, Department of Internal Medicine 2, Medical University of Vienna, Austria.
Schernthaner GH; Division of Angiology, Department of Internal Medicine 2, Medical University of Vienna, Austria.
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Źródło:
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Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2020 Jun 25; Vol. 30 (7), pp. 1179-1187. Date of Electronic Publication: 2020 Apr 07.
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Typ publikacji:
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Journal Article; Observational Study
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Język:
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English
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Imprint Name(s):
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Publication: 2005- : Amsterdam : Elsevier
Original Publication: [Heidelberg] : Springer International, c1991-
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MeSH Terms:
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Anthropometry*
Obesity/*diagnosis
Peripheral Arterial Disease/*mortality
Adiposity ; Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Cause of Death ; Female ; Humans ; Male ; Middle Aged ; Obesity/mortality ; Obesity/physiopathology ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/physiopathology ; Peripheral Arterial Disease/therapy ; Predictive Value of Tests ; Prognosis ; Registries ; Risk Assessment ; Risk Factors ; Time Factors ; Waist Circumference ; Waist-Hip Ratio
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Contributed Indexing:
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Keywords: Atherosclerosis; Mortality; Obesity; Peripheral arterial disease; Risk factors
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Entry Date(s):
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Date Created: 20200527 Date Completed: 20201013 Latest Revision: 20201013
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Update Code:
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20240105
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DOI:
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10.1016/j.numecd.2020.03.019
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PMID:
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32451274
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Background and Aims: Previous data show contradicting results regarding relevance of obesity on outcome in peripheral arterial disease (PAD). Thus, this study aims to evaluate the predictive power of obesity as measured by established and novel obesity indices (waist circumference WC, waist-hip ratio WHR, body-mass index BMI, body adiposity index BAI, visceral adiposity index VAI, weight-adjusted waist index WWI) in a PAD cohort.
Methods and Results: In 367 patients with diagnosed PAD anthropometric parameters were assessed at study inclusion in an observational study. Mortality data was retrieved from the central death registry after five years. Outcome analyses were performed by multivariable Cox-regression models. 57 PAD patients (15.5%) died during the follow-up, of those 36 were categorized as cardiovascular origin. Patients from the all-cause mortality group were older, more often diabetics with a worse glucose control and had worse renal function. Obesity indices were not significantly different between the event and control group. None of the evaluated risk factors predicted cardiovascular or all-cause death after multivariable adjustment for age, gender, LDL-C, serum creatinine, systolic blood pressure, CRP, smoking habits, diabetes status and previous history of peripheral revascularisation (all-cause WC 1.007 (0.983-1.031), WHR 1.772 (0.106-29.595), BMI 1.006 (0.939-1.078), BAI 1.002 (0.945-1.063), VAI 1.019 (0.895-1.161), WWI 1.085 (0.831-1.416); cv-death WC 1.007 (0.978-1.036), WHR 0.382 (0.006-25.338), BMI 1.004 (0.918-1.098), BAI 1.034 (0.959-1.116), VAI 1.036 (0.885-1.213), WWI 1.061 (0.782-1.441)).
Conclusion: Obesity as risk marker estimated by indices both for general and visceral adiposity, does not predict mortality in a secondary prevention cohort of PAD patients.
Competing Interests: Declaration of Competing Interest There are no potential conflicts of interest to declare. This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
(Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
