FDG Uptake in Brown Adipose Tissue Activated by a β3-Adrenergic Receptor Agonist Prescribed for Overactive Bladder.

Szczegóły
Abstrakt

Tytuł:: FDG Uptake in Brown Adipose Tissue Activated by a β3-Adrenergic Receptor Agonist Prescribed for Overactive Bladder.
Autorzy:: Okuyama C; From the Division of PET Imaging, Shiga Medical Center Research Institute.
Kikuchi R; Departments of Thoracic Surgery.
Ikeuchi T; Diagnostic Radiology, Shiga General Hospital, Moriyama, Japan.
Źródło:: Clinical nuclear medicine [Clin Nucl Med] 2020 Aug; Vol. 45 (8), pp. 628-631.
Typ publikacji:: Case Reports; Journal Article
Język:: English
Imprint Name(s):: Original Publication: Philadelphia, Lippincott.
MeSH Terms:: Positron-Emission Tomography*
Acetanilides/*adverse effects
Adipose Tissue, Brown/*diagnostic imaging
Adrenergic Agonists/*adverse effects
Fluorodeoxyglucose F18/*pharmacokinetics
Radiopharmaceuticals/*pharmacokinetics
Thiazoles/*adverse effects
Acetanilides/therapeutic use ; Adipose Tissue, Brown/drug effects ; Adipose Tissue, Brown/metabolism ; Adrenal Gland Neoplasms/diagnostic imaging ; Adrenergic Agonists/therapeutic use ; Aged, 80 and over ; Female ; Humans ; Pheochromocytoma/diagnostic imaging ; Thiazoles/therapeutic use ; Urinary Bladder, Overactive/drug therapy
References:: Perkins AC, Mshelia DS, Symonds ME, et al. Prevalence and pattern of brown adipose tissue distribution of 18F-FDG in patients undergoing PET-CT in a subtropical climatic zone. Nucl Med Commun. 2013;34:168–174.
Esen Akkas B, Gokaslan D, Guner L, et al. FDG uptake in brown adipose tissue—a brief report on brown fat with FDG uptake mechanisms and quantitative analysis using dual-time-point FDG PET/CT. Rev Esp Med Nucl. 2011;30:14–18.
Zukotynski KA, Fahey FH, Laffin S, et al. Constant ambient temperature of 24 degrees C significantly reduces FDG uptake by brown adipose tissue in children scanned during the winter. Eur J Nucl Med Mol Imaging. 2009;36:602–606.
Kuji I, Imabayashi E, Minagawa A, et al. Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma. Ann Nucl Med. 2008;22:231–235.
Li B, Zhang M, Jin J. Unusual FDG uptakes of mesenteric brown adipose tissue in a patient with pheochromocytomas. Nuklearmedizin. 2016;55:N32–N33.
Joshi PV, Lele VR. Unexpected visitor on FDG PET/CT—brown adipose tissue (BAT) in mesentery in a case of retroperitoneal extra-adrenal pheochromocytoma: is the BAT activation secondary to catecholamine-secreting pheochromocytoma? Clin Nucl Med. 2012;37:e119–e120.
Yamaga LY, Thom AF, Wagner J, et al. The effect of catecholamines on the glucose uptake in brown adipose tissue demonstrated by (18)F-FDG PET/CT in a patient with adrenal pheochromocytoma. Eur J Nucl Med Mol Imaging. 2008;35:446–447.
Okuyama C, Sakane N, Yoshida T, et al. (123)I- or (125)I-metaiodobenzylguanidine visualization of brown adipose tissue. J Nucl Med. 2002;43:1234–1240.
Admiraal WM, Holleman F, Bahler L, et al. Combining 123I-metaiodobenzylguanidine SPECT/CT and 18F-FDG PET/CT for the assessment of brown adipose tissue activity in humans during cold exposure. J Nucl Med. 2013;54:208–212.
Cypess AM, Weiner LS, Roberts-Toler C, et al. Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist. Cell Metab. 2015;21:33–38.
Substance Nomenclature:: 0 (Acetanilides)
0 (Adrenergic Agonists)
0 (Radiopharmaceuticals)
0 (Thiazoles)
0Z5B2CJX4D (Fluorodeoxyglucose F18)
MVR3JL3B2V (mirabegron)
Entry Date(s):: Date Created: 20200527 Date Completed: 20201022 Latest Revision: 20210204
Update Code:: 20240105
DOI:: 10.1097/RLU.0000000000003078
PMID:: 32453085
: Czasopismo naukowe

Brown adipose tissue (BAT), which produces energy and is known to play a role as a hibernating gland, is sometimes visualized on F-FDG PET in children or in slender young adults in a cold environment. Because BAT is activated by catecholamines, FDG uptake in BAT is also observed in patients with pheochromocytoma or paraganglioma. We present the case of an elderly woman with remarkable FDG uptake in BAT. Activation of BAT by a β3-adrenergic receptor agonist (mirabegron) prescribed for overactive bladder was suspected as the cause of the marked visualization of BAT in this patient.

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