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Tytuł:
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Temporal dynamics of suspiciousness and hallucinations in clinical high risk and first episode psychosis.
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Autorzy:
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Hermans K; Catholic University Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Contextual Psychiatry, Leuven, Belgium. Electronic address: .
van der Steen Y; Catholic University Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Contextual Psychiatry, Leuven, Belgium; Maastricht University, School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry & Neuropsychology, Maastricht, The Netherlands; GGzE, Institute for Mental Health Care Eindhoven en de Kempen, Eindhoven, The Netherlands.
Kasanova Z; Catholic University Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Contextual Psychiatry, Leuven, Belgium.
van Winkel R; University Psychiatric Center, Catholic University Leuven, Campus Kortenberg, Leuvensesteenweg, Kortenberg, Belgium; Catholic University Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Clinical Psychiatry, Leuven, Belgium.
Reininghaus U; Centre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Lataster T; Maastricht University, School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry & Neuropsychology, Maastricht, The Netherlands.
Bechdolf A; Department of Psychiatry, Psychotherapy and Psychosomatic Medicine with Early Intervention and Recognition Centre (FRITZ), Vivantes Klinikum Am Urban, Charité-Universitätsmedizin, Berlin, Germany; Vivantes Klinikum im Friedrichshain, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Charité-Universitätsmedizin, Berlin, Germany; ORYGEN, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
Gimpel-Drees J; University of Bonn, Department of Psychiatry and Psychotherapy, Bonn, Germany.
Wagner M; University of Bonn, Department of Neurodegenerative Diseases and Geriatric Psychiatry, Bonn, Germany.
Myin-Germeys I; Catholic University Leuven, Department of Neuroscience, Research Group Psychiatry, Center for Contextual Psychiatry, Leuven, Belgium.
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Źródło:
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Psychiatry research [Psychiatry Res] 2020 Aug; Vol. 290, pp. 113039. Date of Electronic Publication: 2020 May 14.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
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MeSH Terms:
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Delusions/*diagnosis
Delusions/*psychology
Hallucinations/*diagnosis
Hallucinations/*psychology
Psychotic Disorders/*diagnosis
Psychotic Disorders/*psychology
Adolescent ; Adult ; Delusions/epidemiology ; Female ; Hallucinations/epidemiology ; Humans ; Male ; Prevalence ; Psychotic Disorders/epidemiology ; Risk Factors ; Time Factors ; Young Adult
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Contributed Indexing:
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Keywords: Early stage psychosis; Experience sampling methodology; Positive psychotic symptoms
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Entry Date(s):
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Date Created: 20200528 Date Completed: 20201208 Latest Revision: 20201214
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Update Code:
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20240105
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DOI:
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10.1016/j.psychres.2020.113039
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PMID:
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32460186
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The objective of the current study is to elucidate the temporal dynamics of suspiciousness and hallucinations as they occur in daily life in the early stages of psychosis. Their prevalence and co-occurrence, as well as their temporal relation to affect and delusions, were compared between patients with a first psychotic episode (FEP) and individuals at clinical high risk for psychosis (CHRp). The Experience Sampling Method was used to investigate suspiciousness and hallucinatory experiences, delusions, and affect at semi-random moments throughout six days in 33 CHRp and 34 FEP. Overall, 91% of CHRp and 59% of FEP reported suspiciousness, and 24% and 39% reported hallucinations, respectively. Hallucinations almost always co-occurred with suspiciousness, whereas suspiciousness was often present without hallucinations. Suspicious episodes in CHRp occurred with marked increases in delusional intensity, while hallucinatory experiences were mostly absent. In FEP, a decrease of positive affect preceded suspicious episodes, while an increase of negative affect preceded hallucinatory episodes. Our results indicated the presence of a delusional mood (atmosphere) in CHRp as an experience in itself, without co-occurring or following hallucinations, thus refuting the anomalous experience hypothesis of psychosis. The co-occurrence of hallucinations, on the other hand, indicates a more severe stage of symptomatology.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2020 Elsevier B.V. All rights reserved.)