Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Comprehensive analysis of T-cell receptor repertoire in patients with acute coronary syndrome by high-throughput sequencing.

Tytuł :
Comprehensive analysis of T-cell receptor repertoire in patients with acute coronary syndrome by high-throughput sequencing.
Autorzy :
Liu S; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China. .; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China. .
Zhong Z; Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizho, 514031, P. R. China.; Center for Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, 514031, P. R. China.
Zhong W; Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizho, 514031, P. R. China.; Center for Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, 514031, P. R. China.
Weng R; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China.
Liu J; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China.
Gu X; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China.
Chen Y; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China.
Pokaż więcej
Źródło :
BMC cardiovascular disorders [BMC Cardiovasc Disord] 2020 May 27; Vol. 20 (1), pp. 253. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: London : BioMed Central, [2001-
MeSH Terms :
Genes, T-Cell Receptor*
High-Throughput Nucleotide Sequencing*
Acute Coronary Syndrome/*genetics
Angina, Unstable/*genetics
Myocardial Infarction/*genetics
T-Lymphocytes/*immunology
Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/immunology ; Aged ; Angina, Unstable/diagnosis ; Angina, Unstable/immunology ; Case-Control Studies ; China ; Complementarity Determining Regions/genetics ; Female ; Genes, T-Cell Receptor beta/genetics ; Humans ; Immunoglobulin Variable Region ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/immunology
References :
Oncoimmunology. 2016 Aug 5;5(10):e1219010. (PMID: 27853640)
Arterioscler Thromb. 1992 Feb;12(2):206-11. (PMID: 1531930)
EMBO Mol Med. 2012 Nov;4(11):1176-85. (PMID: 23023917)
Nat Methods. 2015 May;12(5):380-1. (PMID: 25924071)
Immunol Today. 1995 Jan;16(1):27-33. (PMID: 7880386)
Curr Allergy Asthma Rep. 2016 Apr;16(4):27. (PMID: 26922942)
Genome Res. 2011 May;21(5):790-7. (PMID: 21349924)
Circulation. 2000 Jun 27;101(25):2883-8. (PMID: 10869258)
Nat Immunol. 2011 Mar;12(3):204-12. (PMID: 21321594)
Nature. 1993 Apr 29;362(6423):801-9. (PMID: 8479518)
Cell. 1994 Jan 14;76(1):17-27. (PMID: 8287475)
Circulation. 1999 Nov 23;100(21):2135-9. (PMID: 10571971)
PLoS One. 2016 Mar 28;11(3):e0152464. (PMID: 27019362)
Circulation. 2006 Feb 7;113(5):640-6. (PMID: 16461836)
Sci Rep. 2015 Sep 02;5:13664. (PMID: 26329277)
Hepatology. 2016 May;63(5):1608-19. (PMID: 26257205)
J Transl Med. 2018 Jul 5;16(1):189. (PMID: 29976209)
Nat Rev Immunol. 2004 Feb;4(2):123-32. (PMID: 15040585)
Immunol Rev. 2014 Sep;261(1):50-61. (PMID: 25123276)
BMC Med. 2014 Mar 18;12:47. (PMID: 24642015)
N Engl J Med. 1999 Jan 14;340(2):115-26. (PMID: 9887164)
Oncoimmunology. 2015 Jan 22;4(4):e1001230. (PMID: 26137399)
Stem Cell Investig. 2015 Sep 28;2:17. (PMID: 27358885)
Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):864-70. (PMID: 16456097)
Genome Med. 2013 Oct 30;5(10):98. (PMID: 24172704)
Front Immunol. 2013 Dec 23;4:456. (PMID: 24391640)
J Am Coll Cardiol. 2016 Nov 8;68(19):2107-2117. (PMID: 27810051)
J Exp Med. 2006 May 15;203(5):1273-82. (PMID: 16682495)
Front Immunol. 2016 Aug 31;7:336. (PMID: 27630639)
Nat Med. 2013 Mar;19(3):372-7. (PMID: 23435170)
Nat Rev Nephrol. 2017 Jun;13(6):368-380. (PMID: 28392564)
J Am Coll Cardiol. 2016 Sep 20;68(12):1281-93. (PMID: 27634119)
Oncotarget. 2017 Aug 3;8(59):99312-99322. (PMID: 29245903)
Atherosclerosis. 2011 Sep;218(1):53-60. (PMID: 21621777)
Ann N Y Acad Sci. 2000 May;902:53-62; discussion 62-4. (PMID: 10865825)
Front Immunol. 2013 Nov 27;4:413. (PMID: 24348479)
J Am Heart Assoc. 2016 Sep 20;5(9):. (PMID: 27650878)
Immunity. 2013 Jun 27;38(6):1092-104. (PMID: 23809160)
Circulation. 2000 Dec 12;102(24):2919-22. (PMID: 11113040)
Grant Information :
2018B027 International Science and Technology Program of Meizhou; MPHKSTP-20170101 International Key Scientific and Technological Project of Meizhou People's Hospital
Contributed Indexing :
Keywords: Acute coronary syndrome (ACS)*; Clonotype*; High-throughput sequencing (HTS)*; T-cell receptor (TCR)*
Substance Nomenclature :
0 (Complementarity Determining Regions)
0 (Immunoglobulin Variable Region)
Entry Date(s) :
Date Created: 20200529 Date Completed: 20201130 Latest Revision: 20201130
Update Code :
20210210
PubMed Central ID :
PMC7254720
DOI :
10.1186/s12872-020-01538-6
PMID :
32460698
Czasopismo naukowe
Background: This study aims to investigate the T-cell receptor (TCR) repertoire in patients with acute coronary syndrome (ACS).
Methods: The TCR repertoires of 9 unstable angina patients (UA), 14 acute myocardial infarction patients (AMI) and 9 normal coronary artery (NCA) patients were profiled using high-throughput sequencing (HTS). The clonal diversity of the TCR repertoires in different groups was analyzed, as well as the frequencies of variable (V), diversity (D) and joining(J) gene segments.
Results: ACS patients including UA and AMI, showed reduced TCRβ diversity than NCA patients. ACS patients presented higher levels of clonal expansion. The clonotype overlap of complementarity determining region 3(CDR3) was significantly varied between different groups. A total of 10 V genes and 1 J gene were differently utilized between ACS and NCA patients. We identified some shared CDR3 amino acid sequences that were presented in ACS but not in NCA patients.
Conclusions: This study revealed the distinct TCR repertoires in patients with ACS and demonstrated the presence of disease associated T-cell clonotypes. These findings suggested a role of T cells in ACS and provided a new way to explore the mechanisms of ACS.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies