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Tytuł:
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Black soybean improves the vascular function through an increase in nitric oxide and a decrease in oxidative stress in healthy women.
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Autorzy:
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Yamashita Y; Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan. Electronic address: .
Wang L; Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan.
Nakamura A; Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan.
Nanba F; Fujicco Co. Ltd, Research Development, 6-13-4, Minatojima-Nakamachi, Chuo-Ku, Kobe, 650-8558, Japan.
Saito S; Fujicco Co. Ltd, Research Development, 6-13-4, Minatojima-Nakamachi, Chuo-Ku, Kobe, 650-8558, Japan.
Toda T; Fujicco Co. Ltd, Research Development, 6-13-4, Minatojima-Nakamachi, Chuo-Ku, Kobe, 650-8558, Japan.
Nakagawa J; Nakagawa Clinic, 3-15-4, Higashisonoda-cho, Amagasaki, 661-0953, Japan.
Ashida H; Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan.
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Źródło:
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Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Jul 30; Vol. 688, pp. 108408. Date of Electronic Publication: 2020 May 26.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: <2000- > : San Diego, CA : Elsevier
Original Publication: New York, NY : Academic Press
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MeSH Terms:
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Antioxidants/*pharmacology
Blood Vessels/*drug effects
Nitric Oxide/*metabolism
Oxidative Stress/*drug effects
Polyphenols/*pharmacology
Glycine max/*chemistry
Administration, Oral ; Adult ; Aged ; Animals ; Antioxidants/administration & dosage ; Antioxidants/analysis ; Biomarkers/blood ; Biomarkers/metabolism ; Biomarkers/urine ; Blood Pressure ; Female ; Humans ; Middle Aged ; Nitric Oxide/blood ; Nitric Oxide/urine ; Photoplethysmography ; Polyphenols/administration & dosage ; Polyphenols/blood ; Polyphenols/urine ; Young Adult
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Contributed Indexing:
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Keywords: Black soybean polyphenol; Nitric oxide; Oxidative stress; Polyphenol; Vascular function
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Substance Nomenclature:
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0 (Antioxidants)
0 (Biomarkers)
0 (Polyphenols)
31C4KY9ESH (Nitric Oxide)
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Entry Date(s):
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Date Created: 20200530 Date Completed: 20201005 Latest Revision: 20231213
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Update Code:
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20240104
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DOI:
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10.1016/j.abb.2020.108408
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PMID:
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32470460
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Vascular dysfunction and injurious stimuli such as oxidative stress is closely related to the risk of cardiovascular diseases (CVD). Dietary polyphenols is reported to exert the beneficial effects on reducing the risk of CVD. Black soybean is rich in polyphenols, including isoflavones, anthocyanidins and flavan-3-ols, and its prevention effects on CVD risk were reported in the animal experiments. In this study, we investigated the effect of black soybean consumption on the vascular function and oxidative stress associating with the polyphenol concentrations in healthy women. Lowered vascular age was observed in 33 out of 44 volunteers who completed the 8-week trial. It was observed that improvement of the vascular stiffness, increasing in the urinary NO 2 and NO 3 level, and decreasing in the oxidative stress markers, 8-hydroxy-2'-deoxyguanosine, hexanoyl-lysine and myeloperoxidase. In addition, concentration of 12 polyphenols in black soybean increased in the plasma and urine. Increased concentration of polyphenols would be involved in the decreased oxidative stress. Thus, black soybean consumption improved the vascular function through an increase in nitric oxide and a decrease in oxidative stress accompanied by increasing the polyphenol concentrations in healthy women.
Competing Interests: Declaration of competing interest Fujicco Co. Ltd. partly funded the investigations described in the present manuscript. FN, SS, TT are employees of Fujicco Co. Ltd. They contributed to the study design, data collection and analysis.
(Copyright © 2020. Published by Elsevier Inc.)