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Tytuł:
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Circadian Regulation of Adult Stem Cell Homeostasis and Aging.
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Autorzy:
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Benitah SA; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; ICREA, Catalan Institution for Research and Advanced Studies, 08010 Barcelona, Spain. Electronic address: .
Welz PS; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain. Electronic address: .
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Źródło:
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Cell stem cell [Cell Stem Cell] 2020 Jun 04; Vol. 26 (6), pp. 817-831.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Cambridge, MA : Cell Press
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MeSH Terms:
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Adult Stem Cells*
Circadian Clocks*
Circadian Rhythm ; Homeostasis
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Entry Date(s):
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Date Created: 20200606 Date Completed: 20210427 Latest Revision: 20210427
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Update Code:
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20240104
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DOI:
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10.1016/j.stem.2020.05.002
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PMID:
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32502402
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The circadian clock temporally organizes cellular physiology throughout the day, allowing daily environmental changes to be anticipated and potentially harmful physiologic processes to be temporally separated. By synchronizing all cells at the tissue level, the circadian clock ensures coherent temporal organismal physiology. Recent advances in our understanding of adult stem cell physiology suggest that aging and perturbations in circadian rhythmicity in stem cells are tightly intertwined. Here we discuss how circadian rhythms regulate and synchronize adult stem cell functions and how alterations in clock function during aging modulate the extrinsic and intrinsic mechanisms that determine adult stem cell homeostasis.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
