A new treatment of alopecia induced by palbociclib: Topical cetirizine.

Szczegóły
Abstrakt

Tytuł:: A new treatment of alopecia induced by palbociclib: Topical cetirizine.
Autorzy:: Caro G; Department of Ematology, Oncology and Dermatology, 'Sapienza' University of Rome, Rome, Italy.
Fortuna MC; Department of Ematology, Oncology and Dermatology, 'Sapienza' University of Rome, Rome, Italy.
Magri F; Department of Ematology, Oncology and Dermatology, 'Sapienza' University of Rome, Rome, Italy.
Federico A; Department of Ematology, Oncology and Dermatology, 'Sapienza' University of Rome, Rome, Italy.
Carlesimo M; Department of Ematology, Oncology and Dermatology, 'Sapienza' University of Rome, Rome, Italy.
Rossi A; Department of Ematology, Oncology and Dermatology, 'Sapienza' University of Rome, Rome, Italy.
Źródło:: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners [J Oncol Pharm Pract] 2021 Mar; Vol. 27 (2), pp. 460-463. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji:: Case Reports; Journal Article
Język:: English
Imprint Name(s):: Publication: London : SAGE Publications
Original Publication: Norwalk, CT : Appleton & Lange, c1995-
MeSH Terms:: Alopecia/*chemically induced
Alopecia/*drug therapy
Antineoplastic Agents/*adverse effects
Cetirizine/*therapeutic use
Histamine H1 Antagonists/*therapeutic use
Piperazines/*adverse effects
Protein Kinase Inhibitors/*adverse effects
Pyridines/*adverse effects
Administration, Topical ; Aged ; Breast Neoplasms/complications ; Breast Neoplasms/drug therapy ; Cetirizine/administration & dosage ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Female ; Histamine H1 Antagonists/administration & dosage ; Humans ; Neoplasm Metastasis/drug therapy ; Piperazines/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Pyridines/therapeutic use ; Scalp/pathology ; Treatment Outcome
Contributed Indexing:: Keywords: CDK4/6 inhibitors; Topical cetirizine; alopecia; hair loss; palbociblib
Substance Nomenclature:: 0 (Antineoplastic Agents)
0 (Histamine H1 Antagonists)
0 (Piperazines)
0 (Protein Kinase Inhibitors)
0 (Pyridines)
EC 2.7.11.22 (Cyclin-Dependent Kinases)
G9ZF61LE7G (palbociclib)
YO7261ME24 (Cetirizine)
Entry Date(s):: Date Created: 20200613 Date Completed: 20210329 Latest Revision: 20210329
Update Code:: 20240105
DOI:: 10.1177/1078155220930334
PMID:: 32529951
: Czasopismo naukowe

Introduction: Recently CDK4/6 inhibitors have been introduced for the treatment of hormone positive breast cancer resistant to endocrine therapy. Among their side effects, alopecia is often reported being associated to patients' distress and depressive symptoms.
Case Report: We report the case of a 70-year-old woman affected by breast cancer in treatment with Palbociclib, who developed alopecia.Management and Outcome: We prescribed a topical solution with cetirizine. Global photography, trichoscopy and trichogram were assessed. All evaluations demonstrated alopecia improvement.
Discussion: Currently, no treatment options for CDK 4/6 inhibitors induced alopecia have been proposed. Herein, we report the use of topical cetirizine.

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