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Tytuł:
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Glutamine chelation governs the selective inhibition of Staphylococcus aureus and Salmonella typhi growth by cis-dichloro-bis(8-quinolinolato)zirconium(IV): Theory and experiment.
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Autorzy:
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Narayanan J; Division de Ingeniería en Nanotecnología, Universidad Politécnica del Valle de México, Av. Mexiquense s/n esquina Av. Universidad Politécnica, Tultitlan, Estado de México, CP 54910, México. Electronic address: .
Hernández JG; Centro Tecnológico, Facultad de Estudios Superiores (FES-Aragón), Universidad Nacional Autónoma de México (UNAM), Estado de México, CP 57130, México.
Aguilar CAH; Division de Ingeniería en Nanotecnología, Universidad Politécnica del Valle de México, Av. Mexiquense s/n esquina Av. Universidad Politécnica, Tultitlan, Estado de México, CP 54910, México.
Rodríguez MM; Division de Ingeniería en Nanotecnología, Universidad Politécnica del Valle de México, Av. Mexiquense s/n esquina Av. Universidad Politécnica, Tultitlan, Estado de México, CP 54910, México.
Cerda SDG; Division de Ingeniería en Nanotecnología, Universidad Politécnica del Valle de México, Av. Mexiquense s/n esquina Av. Universidad Politécnica, Tultitlan, Estado de México, CP 54910, México.
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Źródło:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2020 Aug 01; Vol. 151, pp. 105427. Date of Electronic Publication: 2020 Jun 13.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier Science B.V
Original Publication: Amsterdam ; New York : Elsevier, c1993-
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MeSH Terms:
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Staphylococcal Infections*
Staphylococcus aureus*
Glutamine ; Humans ; Salmonella typhi ; Zirconium
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Contributed Indexing:
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Keywords: Amino acid bindings; Salmonella typhi; Schiff base zirconium(IV) complex; Staphylococcus aureus; TD-DFT
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Substance Nomenclature:
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0RH81L854J (Glutamine)
C6V6S92N3C (Zirconium)
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Entry Date(s):
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Date Created: 20200617 Date Completed: 20210621 Latest Revision: 20210621
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Update Code:
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20240105
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DOI:
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10.1016/j.ejps.2020.105427
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PMID:
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32544422
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Quinolone-based Schiff base zirconium(IV) complex was studied as potential bacterial inhibitor against Gram-positive Staphylococcus aureus and Gram-negative Salmonella typhi growth, showing that the interaction of the complex with L-glutamine which presents in the membrane of wall leads cell death, and the mode of bacterial interaction was analyzed theoretically by DFT. Furthermore, the interaction of different amino acid residues L-alanine, D-alanine, L-lysine and D-glutamine with the metal complex through UV-vis docking studies was conducted observing that D-glutamine interacts efficiently among other amino acid residues. This observation is consistent with the interaction of the metal complex that was effective when participating in an insight of the peptidoglycan cell wall since the binding nature of glutamine potentially inhibits these microorganisms.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
