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Tytuł pozycji:

δ-Catenin engages the autophagy pathway to sculpt the developing dendritic arbor.

Tytuł :
δ-Catenin engages the autophagy pathway to sculpt the developing dendritic arbor.
Autorzy :
Ligon C; Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Seong E; Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Schroeder EJ; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
DeKorver NW; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Yuan L; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Chaudoin TR; Division of Geriatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Cai Y; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Buch S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Bonasera SJ; Division of Geriatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Arikkath J; Department of Anatomy, Howard University, Washington, D. C., USA .
Pokaż więcej
Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Aug 07; Vol. 295 (32), pp. 10988-11001. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język :
English
Imprint Name(s) :
Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology
Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology
MeSH Terms :
Autophagy*
Catenins/*metabolism
Dendritic Cells/*metabolism
Animals ; Autophagy-Related Protein 7/genetics ; Catenins/genetics ; Cells, Cultured ; Gene Knockdown Techniques ; Hippocampus/cytology ; Hippocampus/metabolism ; Mice ; Pyramidal Cells/metabolism ; Rats
References :
Front Cell Neurosci. 2015 Aug 11;9:314. (PMID: 26321915)
Nature. 2007 Jun 14;447(7146):859-63. (PMID: 17568747)
Neuron. 2018 Feb 7;97(3):727. (PMID: 29420936)
Front Mol Neurosci. 2017 Aug 22;10:263. (PMID: 28878620)
Biol Psychiatry. 2020 May 1;87(9):787-796. (PMID: 31542152)
Nat Neurosci. 2017 Aug;20(8):1114-1121. (PMID: 28628104)
J Biol Chem. 2018 Jul 20;293(29):11625-11638. (PMID: 29875160)
Nat Protoc. 2012 Sep;7(9):1741-54. (PMID: 22936216)
Gene. 2015 Jul 1;565(1):146-9. (PMID: 25839933)
Neuron. 2014 Sep 3;83(5):1131-43. (PMID: 25155956)
Autophagy. 2012 May 1;8(5):858-60. (PMID: 22617438)
EMBO J. 2017 Oct 16;36(20):2931-2950. (PMID: 28916614)
J Cell Biol. 2017 Jul 3;216(7):1895-1906. (PMID: 28515275)
Autophagy. 2016;12(2):225-44. (PMID: 26902584)
Neuron. 2017 Jan 18;93(2):379-393. (PMID: 28065648)
J Cell Sci. 2015 Apr 1;128(7):1259-67. (PMID: 25829512)
Autophagy. 2020 Mar;16(3):391-407. (PMID: 31142229)
Nat Neurosci. 2015 Dec;18(12):1713-21. (PMID: 26605882)
Curr Opin Neurobiol. 2019 Aug;57:141-148. (PMID: 30861464)
J Neurosci. 2016 Jun 1;36(22):5933-45. (PMID: 27251616)
Neuron. 2013 Dec 18;80(6):1438-50. (PMID: 24360546)
Nat Genet. 2013 Apr;45(4):445-9, 449e1. (PMID: 23435086)
Nature. 2015 Apr 2;520(7545):51-6. (PMID: 25807484)
Neuron. 2012 Apr 26;74(2):277-84. (PMID: 22542182)
J Neurosci. 2008 Jul 9;28(28):7047-56. (PMID: 18614673)
Elife. 2019 Aug 28;8:. (PMID: 31461398)
Neuron. 2002 Aug 29;35(5):921-33. (PMID: 12372286)
Trends Neurosci. 2013 Jul;36(7):418-28. (PMID: 23639383)
Nat Neurosci. 2014 Apr;17(4):522-32. (PMID: 24562000)
J Cell Biol. 2017 Feb;216(2):477-493. (PMID: 28053206)
Nat Neurosci. 2019 Apr;22(4):618-626. (PMID: 30858601)
Curr Opin Neurobiol. 2019 Feb;54:1-11. (PMID: 30036841)
Mol Cell Neurosci. 2012 May;50(1):10-20. (PMID: 22465229)
Mol Cell Biol. 2013 Oct;33(19):3907-19. (PMID: 23918799)
Cell. 2015 Aug 13;162(4):808-22. (PMID: 26255771)
Cell Rep. 2019 Nov 19;29(8):2422-2437.e8. (PMID: 31747610)
J Neurosci. 2019 Mar 20;39(12):2163-2183. (PMID: 30655355)
Neuron. 2006 Jul 6;51(1):43-56. (PMID: 16815331)
Mol Neurobiol. 2018 Aug;55(8):6269-6281. (PMID: 29294243)
Neuron. 2017 Jun 21;94(6):1155-1172.e8. (PMID: 28641114)
Nature. 2006 Jun 15;441(7095):880-4. (PMID: 16625205)
Dev Cell. 2014 Jul 14;30(1):71-85. (PMID: 25026034)
FEBS J. 2016 Jul;283(13):2403-13. (PMID: 26854402)
Cell Mol Life Sci. 2017 Dec;74(23):4369-4385. (PMID: 28698933)
Curr Opin Neurobiol. 2019 Oct;58:78-85. (PMID: 31419712)
Genomics. 2000 Jan 15;63(2):157-64. (PMID: 10673328)
Nature. 2008 Feb 28;451(7182):1069-75. (PMID: 18305538)
Neuron. 2009 Nov 12;64(3):320-7. (PMID: 19914181)
Autophagy. 2010 Oct;6(7):991-3. (PMID: 20818165)
J Cell Biol. 2016 Oct 24;215(2):245-258. (PMID: 27810915)
Nature. 2017 May 4;545(7652):108-111. (PMID: 28445460)
J Neurosci. 2009 Apr 29;29(17):5435-42. (PMID: 19403811)
Neuron. 2017 Feb 22;93(4):897-913.e7. (PMID: 28231469)
Cell. 2014 Sep 11;158(6):1335-1347. (PMID: 25201528)
Annu Rev Biochem. 2016 Jun 2;85:685-713. (PMID: 26865532)
Brain Cell Biol. 2006 Feb;35(1):29-38. (PMID: 17940911)
J Biol Chem. 2008 Jan 11;283(2):977-87. (PMID: 17993462)
Hum Genet. 2016 Oct;135(10):1107-16. (PMID: 27380241)
Annu Rev Cell Dev Biol. 2015;31:741-77. (PMID: 26422333)
Curr Biol. 2004 Sep 21;14(18):1657-63. (PMID: 15380068)
Front Neurosci. 2017 Aug 03;11:442. (PMID: 28824365)
Nat Rev Neurosci. 2008 Mar;9(3):206-21. (PMID: 18270515)
Neuron. 2011 Mar 10;69(5):885-92. (PMID: 21382549)
J Cell Biol. 2003 Jul 7;162(1):99-111. (PMID: 12835311)
Nat Neurosci. 2010 Jul;13(7):805-11. (PMID: 20581817)
Front Cell Neurosci. 2012 Dec 28;6:61. (PMID: 23293584)
Neuron. 2017 Mar 8;93(5):1015-1034. (PMID: 28279350)
eNeuro. 2016 Oct 28;3(5):. (PMID: 27822498)
Mol Psychiatry. 2018 Mar;23(3):747-758. (PMID: 28167836)
J Cell Biol. 2012 Feb 20;196(4):407-17. (PMID: 22331844)
Neuron. 2005 Dec 8;48(5):757-71. (PMID: 16337914)
Curr Opin Neurobiol. 2010 Aug;20(4):494-502. (PMID: 20800473)
PLoS One. 2015 Feb 23;10(2):e0118482. (PMID: 25705877)
Nat Neurosci. 2010 May;13(5):567-76. (PMID: 20383138)
Neuron. 2016 Mar 2;89(5):1016-30. (PMID: 26898780)
Nature. 2012 Nov 22;491(7425):599-602. (PMID: 23103868)
Neuron. 2016 Nov 23;92(4):829-844. (PMID: 27720484)
J Biol Chem. 2015 Apr 24;290(17):10947-57. (PMID: 25724647)
J Biol Chem. 2008 Nov 21;283(47):32781-91. (PMID: 18809680)
Neuron. 2017 Sep 27;96(1):160-176.e8. (PMID: 28957665)
Nat Commun. 2017 Apr 07;8:14819. (PMID: 28387218)
Nat Rev Neurosci. 2015 Jun;16(6):345-57. (PMID: 25991442)
J Neurosci. 2015 Apr 15;35(15):6179-94. (PMID: 25878289)
Grant Information :
P20 GM103471 United States GM NIGMS NIH HHS; R01 AG031158 United States AG NIA NIH HHS; R01 MH106425 United States MH NIMH NIH HHS; R03 MH110726 United States MH NIMH NIH HHS
Contributed Indexing :
Keywords: ATG7*; autism*; autophagy*; catenin delta 2 (CTNND2)*; dendrite*; dendritic arbor*; development*; hippocampal neurons*; hippocampus*; neuron*; neuronal development*; δ-catenin*
Substance Nomenclature :
0 (Atg7 protein, rat)
0 (Catenins)
0 (delta catenin)
EC 6.2.1.45 (Autophagy-Related Protein 7)
Entry Date(s) :
Date Created: 20200620 Date Completed: 20210219 Latest Revision: 20210808
Update Code :
20210809
PubMed Central ID :
PMC7415987
DOI :
10.1074/jbc.RA120.013058
PMID :
32554807
Czasopismo naukowe
The development of the dendritic arbor in pyramidal neurons is critical for neural circuit function. Here, we uncovered a pathway in which δ-catenin, a component of the cadherin-catenin cell adhesion complex, promotes coordination of growth among individual dendrites and engages the autophagy mechanism to sculpt the developing dendritic arbor. Using a rat primary neuron model, time-lapse imaging, immunohistochemistry, and confocal microscopy, we found that apical and basolateral dendrites are coordinately sculpted during development. Loss or knockdown of δ-catenin uncoupled this coordination, leading to retraction of the apical dendrite without altering basolateral dendrite dynamics. Autophagy is a key cellular pathway that allows degradation of cellular components. We observed that the impairment of the dendritic arbor resulting from δ-catenin knockdown could be reversed by knockdown of autophagy-related 7 (ATG7), a component of the autophagy machinery. We propose that δ-catenin regulates the dendritic arbor by coordinating the dynamics of individual dendrites and that the autophagy mechanism may be leveraged by δ-catenin and other effectors to sculpt the developing dendritic arbor. Our findings have implications for the management of neurological disorders, such as autism and intellectual disability, that are characterized by dendritic aberrations.
(© 2020 Ligon et al.)

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