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Tytuł pozycji:

δ-Catenin engages the autophagy pathway to sculpt the developing dendritic arbor.

Tytuł:
δ-Catenin engages the autophagy pathway to sculpt the developing dendritic arbor.
Autorzy:
Ligon C; Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Seong E; Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Schroeder EJ; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
DeKorver NW; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Yuan L; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Chaudoin TR; Division of Geriatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Cai Y; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Buch S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Bonasera SJ; Division of Geriatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Arikkath J; Department of Anatomy, Howard University, Washington, D. C., USA .
Źródło:
The Journal of biological chemistry [J Biol Chem] 2020 Aug 07; Vol. 295 (32), pp. 10988-11001. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język:
English
Imprint Name(s):
Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology
Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology
MeSH Terms:
Autophagy*
Catenins/*metabolism
Dendritic Cells/*metabolism
Animals ; Autophagy-Related Protein 7/genetics ; Catenins/genetics ; Cells, Cultured ; Gene Knockdown Techniques ; Hippocampus/cytology ; Hippocampus/metabolism ; Mice ; Pyramidal Cells/metabolism ; Rats ; Delta Catenin
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Grant Information:
P20 GM103471 United States GM NIGMS NIH HHS; R01 AG031158 United States AG NIA NIH HHS; R01 MH106425 United States MH NIMH NIH HHS; R03 MH110726 United States MH NIMH NIH HHS
Contributed Indexing:
Keywords: ATG7; autism; autophagy; catenin delta 2 (CTNND2); dendrite; dendritic arbor; development; hippocampal neurons; hippocampus; neuron; neuronal development; δ-catenin
Substance Nomenclature:
0 (Atg7 protein, rat)
0 (Catenins)
EC 6.2.1.45 (Autophagy-Related Protein 7)
0 (Delta Catenin)
Entry Date(s):
Date Created: 20200620 Date Completed: 20210219 Latest Revision: 20221207
Update Code:
20240105
PubMed Central ID:
PMC7415987
DOI:
10.1074/jbc.RA120.013058
PMID:
32554807
Czasopismo naukowe
The development of the dendritic arbor in pyramidal neurons is critical for neural circuit function. Here, we uncovered a pathway in which δ-catenin, a component of the cadherin-catenin cell adhesion complex, promotes coordination of growth among individual dendrites and engages the autophagy mechanism to sculpt the developing dendritic arbor. Using a rat primary neuron model, time-lapse imaging, immunohistochemistry, and confocal microscopy, we found that apical and basolateral dendrites are coordinately sculpted during development. Loss or knockdown of δ-catenin uncoupled this coordination, leading to retraction of the apical dendrite without altering basolateral dendrite dynamics. Autophagy is a key cellular pathway that allows degradation of cellular components. We observed that the impairment of the dendritic arbor resulting from δ-catenin knockdown could be reversed by knockdown of autophagy-related 7 (ATG7), a component of the autophagy machinery. We propose that δ-catenin regulates the dendritic arbor by coordinating the dynamics of individual dendrites and that the autophagy mechanism may be leveraged by δ-catenin and other effectors to sculpt the developing dendritic arbor. Our findings have implications for the management of neurological disorders, such as autism and intellectual disability, that are characterized by dendritic aberrations.
Competing Interests: Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
(© 2020 Ligon et al.)

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