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Tytuł:
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Amphetamine-induced striatal dopamine release in schizotypal personality disorder.
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Autorzy:
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Thompson JL; Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY, 14642, USA. judy_.; Department of Psychiatric Rehabilitation and Counseling Professions, Rutgers University, Piscataway, NJ, 08854, USA. judy_.
Rosell DR; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Slifstein M; Department of Psychiatry, Stony Brook University, Stony Brook, NY, 11794, USA.
Xu X; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.
Rothstein EG; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; The Graduate Center, City University of New York, New York, NY, 10016, USA.
Modiano YA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, 77030, USA.
Kegeles LS; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.; Department of Radiology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.
Koenigsberg HW; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Outpatient Psychiatry, James J. Peters Veterans Affairs Medical Center, Bronx, NY, 10468, USA.
New AS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Hazlett EA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters Veterans Affairs Medical Center, Bronx, NY, 10468, USA.
McClure MM; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Psychology, Fairfield University, Fairfield, CT, 06824, USA.
Perez-Rodriguez MM; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Siever LJ; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Outpatient Psychiatry, James J. Peters Veterans Affairs Medical Center, Bronx, NY, 10468, USA.; Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters Veterans Affairs Medical Center, Bronx, NY, 10468, USA.
Abi-Dargham A; Department of Psychiatry, Stony Brook University, Stony Brook, NY, 11794, USA.
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Źródło:
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Psychopharmacology [Psychopharmacology (Berl)] 2020 Sep; Vol. 237 (9), pp. 2649-2659. Date of Electronic Publication: 2020 Jun 22.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Berlin, New York, Springer-Verlag.
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MeSH Terms:
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Amphetamine/*pharmacology
Corpus Striatum/*drug effects
Corpus Striatum/*metabolism
Dopamine/*metabolism
Dopamine Uptake Inhibitors/*pharmacology
Schizotypal Personality Disorder/*metabolism
Adolescent ; Adult ; Corpus Striatum/diagnostic imaging ; Female ; Humans ; Male ; Memory, Short-Term/drug effects ; Memory, Short-Term/physiology ; Middle Aged ; Positron-Emission Tomography/methods ; Raclopride ; Receptors, Dopamine D2/metabolism ; Schizotypal Personality Disorder/diagnostic imaging ; Schizotypal Personality Disorder/psychology ; Young Adult
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Grant Information:
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MH56140 United States MH NIMH NIH HHS; IK6 CX001738 United States CX CSRD VA; I01CX000609 U.S. Department of Veterans Affairs; I01 CX001451 United States CX CSRD VA; I01 CX002093 United States CX CSRD VA
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Contributed Indexing:
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Keywords: Disorganized symptoms; Dopamine; PET; Positive symptoms; Schizophrenia; Schizotypal personality disorder; Striatum; Working memory
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Substance Nomenclature:
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0 (DRD2 protein, human)
0 (Dopamine Uptake Inhibitors)
0 (Receptors, Dopamine D2)
430K3SOZ7G (Raclopride)
CK833KGX7E (Amphetamine)
VTD58H1Z2X (Dopamine)
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Entry Date(s):
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Date Created: 20200624 Date Completed: 20201223 Latest Revision: 20210211
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Update Code:
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20240105
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DOI:
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10.1007/s00213-020-05561-5
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PMID:
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32572588
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Rationale: Previous research has suggested that schizotypal personality disorder (SPD), a condition that shares clinical and cognitive features with schizophrenia, may be associated with elevated striatal dopamine functioning; however, there are no published studies of dopamine release within subregions of the striatum in SPD.
Objectives: To characterize dopamine release capacity in striatal subregions and its relation to clinical and cognitive features in SPD.
Methods: We used positron emission tomography with [ 11 C]raclopride and an amphetamine challenge to measure dopamine D2-receptor availability (binding potential, BP ND ), and its percent change post-amphetamine (∆BP ND ) to index amphetamine-induced dopamine release, in subregions of the striatum in 16 SPD and 16 healthy control participants. SPD participants were evaluated with measures of schizotypal symptom severity and working memory.
Results: There were no significant group differences in BP ND or ∆BP ND in any striatal subregion or whole striatum. Among SPD participants, cognitive-perceptual symptoms were associated at trend level with ∆BP ND in the ventral striatum, and disorganized symptoms were significantly negatively related to ∆BP ND in several striatal subregions.
Conclusions: In contrast to previous findings, SPD was not associated with elevated striatal dopamine release. However, in SPD, there was a moderate positive association between ventral striatal dopamine release and severity of cognitive-perceptual symptoms, and negative associations between striatal dopamine release and severity of disorganized symptoms. Future larger scale investigations that allow for the separate examination of subgroups of participants based on clinical presentation will be valuable in further elucidating striatal DA functioning in SPD.
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