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Title of the item:

Mycoplasma Pneumoniae-Induced Rash and Mucositis: A Longitudinal Perspective and Proposed Management Criteria.

Title :
Mycoplasma Pneumoniae-Induced Rash and Mucositis: A Longitudinal Perspective and Proposed Management Criteria.
Authors :
Gise R; Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. Electronic address: .
Elhusseiny AM; Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Scelfo C; Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Mantagos IS; Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
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Source :
American journal of ophthalmology [Am J Ophthalmol] 2020 Nov; Vol. 219, pp. 351-356. Date of Electronic Publication: 2020 Jun 20.
Publication Type :
Journal Article; Research Support, Non-U.S. Gov't
Language :
English
Imprint Name(s) :
Publication: 1999- : New York, NY : Elsevier Science
Original Publication: [Chicago, etc., Ophthalmic Pub. Co., etc.]
MeSH Terms :
Amnion/*transplantation
Exanthema/*microbiology
Eye Infections, Bacterial/*microbiology
Eyelid Diseases/*microbiology
Glucocorticoids/*therapeutic use
Mucositis/*microbiology
Mycoplasma pneumoniae/*isolation & purification
Pneumonia, Mycoplasma/*microbiology
Adolescent ; Child ; DNA, Bacterial/genetics ; Exanthema/diagnosis ; Exanthema/therapy ; Eye Infections, Bacterial/diagnosis ; Eye Infections, Bacterial/therapy ; Eyelid Diseases/diagnosis ; Eyelid Diseases/therapy ; Female ; Follow-Up Studies ; Humans ; Immunoglobulin M/blood ; Male ; Mucositis/diagnosis ; Mucositis/therapy ; Mycoplasma pneumoniae/genetics ; Mycoplasma pneumoniae/immunology ; Pneumonia, Mycoplasma/diagnosis ; Pneumonia, Mycoplasma/therapy ; Polymerase Chain Reaction ; Retrospective Studies ; Visual Acuity/physiology
Substance Nomenclature :
0 (DNA, Bacterial)
0 (Glucocorticoids)
0 (Immunoglobulin M)
Entry Date(s) :
Date Created: 20200624 Date Completed: 20201221 Latest Revision: 20201221
Update Code :
20210623
DOI :
10.1016/j.ajo.2020.06.010
PMID :
32574770
Academic Journal
Purpose: To evaluate the natural history and ophthalmologic morbidity of Mycoplasma pneumoniae-induced rash and mucositis (MIRM) and propose a treatment algorithm.
Design: Retrospective, interventional case series.
Methods: Retrospective chart review of all MIRM patients examined by the department of ophthalmology at a tertiary children's hospital. Diagnosis was established clinically concomitant with either positive Mycoplasma pneumoniae IgM or PCR testing from January 1, 2010, until December 31, 2019. The main outcome measures were best-corrected visual acuity, long-term ocular sequelae, and duration and type of ophthalmic intervention.
Results: There were 15 patients (10 male and 5 female) aged 10.9 ± 4.2 years who had primary episodes of MIRM; of those, 4 had multiple episodes. All patients required topical steroid treatment, 3 required amniotic membrane transplantation, and 1 patient underwent placement of a sutureless biologic corneal badage device. There were no patients who suffered visual loss, but 1 was left with mild symblephara near the lateral canthus in each eye and 2 others had scarring of the eyelid margins and blepharitis.
Conclusions: The ocular morbidity is significantly less in MIRM than in other closely related syndromes such as erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis. However, these patients still require close observation and a low threshold for intervention to avoid permanent ophthalmic sequelae and possible blindness.
(Copyright © 2020 Elsevier Inc. All rights reserved.)

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